Results 71 to 80 of about 4,567,035 (352)

Point-of-contact Interactive Record Linkage (PIRL): A software tool to prospectively link demographic surveillance and health facility data [version 1; referees: 2 approved]

open access: yesGates Open Research, 2017
Linking a health and demographic surveillance system (HDSS) to data from a health facility that serves the HDSS population generates a research infrastructure for directly observed data on access to and utilization of health facility services.
Christopher T. Rentsch   +12 more
doaj   +1 more source

Improving Child Health Care Through Federal Policy: An Emerging Opportunity [PDF]

open access: yes, 2008
Summarizes legislative proposals introduced in 2007 to track primary care outcomes in Medicaid and State Children's Health Insurance Programs (SCHIP) and focus on strengthening primary, preventive, and developmental child health services and ...
Carla Plaza   +2 more
core  

Getting research findings into practice : when to act on the evidence. [PDF]

open access: yes, 1998
There is increasing interest in providing evidence based health care—that is, care in which healthcare professionals, provider managers, those who commission health care, the public, and policymakers consistently consider research evidence when making ...
Guyatt, G H, Haines, A, Sheldon, T A
core   +1 more source

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

open access: yesMolecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez   +5 more
wiley   +1 more source

Patient predictors of poor drug sensitive tuberculosis treatment outcomes in Kyiv Oblast, Ukraine [version 2; peer review: 2 approved, 1 approved with reservations]

open access: yesF1000Research, 2018
Background: Ukraine has high rates of poor treatment outcomes among drug sensitive tuberculosis (DSTB) patients, while global treatment success rates for DSTB remain high.
Omowunmi Aibana   +7 more
doaj   +1 more source

Comprehensive Services: Charting Progress for Babies in Child Care Research-Based Rationale [PDF]

open access: yes, 2009
This rationale presents research on factors that put babies and toddlers at risk for unhealthy development and the benefits of comprehensive health, mental health, and family support services.
Elizabeth Hoffmann
core  

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

How blockchain-timestamped protocols could improve the trustworthiness of medical science [version 2; referees: 2 approved]

open access: yesF1000Research, 2016
Trust in scientific research is diminished by evidence that data are being manipulated. Outcome switching, data dredging and selective publication are some of the problems that undermine the integrity of published research.
Greg Irving, John Holden
doaj   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

open access: yesMolecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi   +12 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

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