Results 221 to 230 of about 12,741,957 (410)

Obsessive-compulsive disorder in the World Mental Health surveys. [PDF]

BMC Med
Stein DJ, Ruscio AM, Altwaijri Y, Chiu WT, Sampson NA, Aguilar-Gaxiola S, Al-Hamzawi A, Alonso J, Chardoul S, Gureje O, Hu C, Karam EG, McGrath JJ, Navarro-Mateu F, Scott KM, Stagnaro JC, Torres Y, Vladescu C, Wciórka J, Xavier M, Kessler RC, World Mental Health Survey collaborators.   +21 more
europepmc   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

No easy answer for how to tackle Mexico's health challenges

The Lancet Global Health, 2016
Juan Pablo Gutiérrez, Sebastián García-Saisó   +1 more
doaj   +1 more source

Estimating treatment coverage for people with substance use disorders: an analysis of data from the World Mental Health Surveys

World Psychiatry, 2017
L. Degenhardt, M. Glantz, S. Evans-Lacko, E. Sadikova, N. Sampson, G. Thornicroft, S. Aguilar-Gaxiola, A. Al-Hamzawi, J. Alonso, Laura Helena Andrade, R. Bruffaerts, B. Bunting, E. Bromet, José Miguel Caldas de Almeida, G. de Girolamo, S. Florescu, O. Gureje, Josep María Haro, Yueqin Huang, A. Karam, E. Karam, A. Kiejna, Sing Lee, J. Lépine, D. Levinson, María Elena Medina‐Mora, Yosikazu Nakamura, F. Navarro-Mateu, B. Pennell, J. Posada-Villa, K. Scott, D. Stein, M. ten Have, Y. Torres, Z. Zarkov, S. Chatterji, R. Kessler   +36 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Sex differences in hypercholesterolemia management (2002-2022): evidence from the Swiss National Health Surveys. [PDF]

Prev Med Rep
Yi S, de La Harpe R, Marques-Vidal P.
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Tendência secular da anemia na infância na cidade de São Paulo (1984-1996)

Revista de Saúde Pública
OBJETIVO: Estimar a prevalência e a distribuição social da anemia na infância, estabelecer a tendência secular dessa enfermidade e analisar sua determinação, com base em dados coletados por dois inquéritos domiciliares realizados na cidade de São Paulo ...
Carlos Augusto Monteiro, Sophia Cornbluth Szarfarc, Lenise Mondini   +2 more
doaj  

Trends of diabetes and pre-diabetes in Indonesia 2013-2023: a serial analysis of national health surveys. [PDF]

BMJ Open
Muharram FR, Swannjo JB, Melbiarta RR, Martini S.   +3 more
europepmc   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source