Results 141 to 150 of about 41,645,780 (407)

Health Care for Veterans: Answers to Frequently Asked Questions [PDF]

open access: yes, 2015
The Veterans Health Administration (VHA), within the Department of Veterans Affairs (VA), operates the nation’s largest integrated direct health care delivery system, provides care to approximately 6.6 million unique veteran patients, and employs more ...
Panangala, Sidath Viranga
core   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Knowledge and practice of health managers in using information technology in health system

open access: yesJournal of Health Sciences, 2011
Introduction: Information systems today are an inevitable link in the health care system. Health care institutions and health workers in modern society, depend on information systems in everyday tasks of organizing institutions.The goals of the study ...
Suvada Švrakić, Amer Ovčina
doaj   +1 more source

Health Systems Science

open access: yesAdvances in Pediatrics, 2021
Bartoletta, Katherine M.   +1 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mexico’s Seguro Popular: Achievements and Challenges

open access: yesHealth Systems & Reform, 2018
In Mexico, Seguro Popular is a landmark government program aimed to guarantee universal access to health services, especially for the most vulnerable populations.
Antonio Chemor Ruiz   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The Role Of Local Authorities In Health Issues: A Policy Document Analysis [PDF]

open access: yes, 2015
Prior to the passing of the Health and Social Care Act 2012 the Communities and Local Government (CLG) Select Committee conducted an investigation into the proposed changes to the Public Health System in England.
Coleman, A.   +3 more
core  

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