Results 101 to 110 of about 2,763,321 (346)

Building a People-Centred Integrated Care Model in Urban China: A Qualitative Study of the Health Reform in Luohu

International Journal of Integrated Care, 2020
Introduction: China has adopted a people-centred integrated care model to reform its severely hospitalcentric and fragmented delivery system. As a template of this model in urban China, the Luohu Hospital Group has generated considerable public and ...
Di Liang, Lin Mei, Yingyao Chen, Ping Zhou, Xiaoguang Yang, Jiayan Huang   +5 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Assessing the learning curve effect in health technologies: Lessons from the non-clinical literature [PDF]

, 2002
Introduction: Many health technologies exhibit some form of learning effect, and this represents a barrier to rigorous assessment. It has been shown that the statistical methods used are relatively crude.
Garthwaite, Paul H., Grant, Adrian M., Monk, Andrew F., Ramsay, Craig R., Russell, Ian T., Wallace, Sheila A.   +5 more
core  

Health technology assessment: a primer for ophthalmology [PDF]

, 2018
Rising healthcare costs and increasing demands for health care require techniques to choose between competing uses and even rationing of health care.
Byrne, Sinead, McElnea, Elizabeth, Murphy, Aileen   +2 more
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Cost-Effectiveness Analysis of CT-Based Finite Element Modeling for Osteoporosis Screening in Secondary Fracture Prevention: An Early Health Technology Assessment in the Netherlands

, 2023
Jieyi Li, Marco Viceconti, Xinshan Li, Pinaki Bhattacharya, David Naimark, Anwar Osseyran   +5 more
openalex   +1 more source

EXOGEN ultrasound bone healing system for long bone fractures with non-union or delayed healing: a NICE medical technology guidance [PDF]

, 2014
Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and the source are ...
Ailish Higgins, B Campbell, B Livani, C Rubin, Catherine Meads, D Gebauer, E Mayr, I Willits, J White, Joanne Lord, K Withers, LJ Donaldson, M Schofer, M Taylor, Matthew Glover, PA Nolte, S Jingushi, S Rutten, Susan Bayliss, Yaling Yang   +19 more
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

How to Undertake a Clinically Relevant Systematic Review in a Rapidly Evolving Field: Magnetic Resonance Angiography [PDF]

, 2002
Objectives: The aim was to determine which generations of the evolving technology of magnetic resonance angiography (MRA) are currently of clinical relevance in two clinical applications. Our purpose was to plan a systematic review that would be valuable
Airey, C.M., Bamford, J.M., Berry, E., Cullingworth, J., Davies, L.M., Gough, M.J., Kelly, S., Meaney, J.F.M., Smith, M.A., Westwood, M.E.   +9 more
core  

Budgeting and health technology assessment: First evidence obtained from proposal forms used to submit the adoption of new technology [PDF]

, 2008
Objectives: The aim of this study was to benchmark the proposal forms used by a sample of Italian hospitals to inform the budget process for the adoption of new technology to understand the relationship with the guidelines provided by the Health ...
LETTIERI E, MASELLA C., NOCCO U
core   +1 more source