Results 101 to 110 of about 12,527,178 (304)
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
RETENTION OF REMOTE PUBLIC HEALTH CENTER DOCTOR IN NORTH KONAWE DISTRICT
Jurnal Administrasi Kesehatan IndonesiaBackground: Remote public health centers (PHCs) have the highest proportion of PHCs without doctors, with Southeast Sulawesi Province ranking fifth in this regard. PHCs serve as the main gateway to health services in rural and remote areas.
Sondang Whita Kristina Tambun +1 more
doaj +1 more source
Essential public health functions: a guide to map and measure national workforce capacity
ix, 42 p.Strengthening the capacity of the workforce delivering essential public health functions (EPHFs) is critical for achieving universal health coverage and improving preparedness for health emergencies in an increasingly complex risk environment ...
World Health Organization
core
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
2018 Indiana Health Workforce Summit Presentations
, 2018 The 2018 Indiana Health Workforce Summit provided attendees the opportunity to learn and engage in discussions on top health workforce initiatives and priorities in Indiana.
Bowen Center for Health Workforce Research & Policy
core +1 more source
x, 30 p.This operational handbook supports country-led contextualization and implementation of the World Health Organization’s roadmap on national workforce capacity for essential public health functions (EPHFs). Developed in response to lessons from the
World Health Organization
core