Results 111 to 120 of about 12,527,178 (304)
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Defining essential public health functions and services to strengthen national workforce capacity
vi, 28 p.This technical guidance document supports countries in operationalizing the essential public health functions (EPHFs) as part of efforts to strengthen national public health workforce capacity and improve health system resilience.
World Health Organization
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Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Scientific ReportsImproving physical balance among older workers is essential for preventing falls in workplace. We aimed to elucidate the age-related decline in one-leg standing time with eyes closed, an indicator of static balance, and mitigating influence of daily ...
Kazuhiko Watanabe +6 more
doaj +1 more source
, 2014 Summary: Access to reliable, comprehensive, timely and nationally consistent trend data is required to understand the current health workforce and for its future planning. There is particular interest in changes to the size and composition of the various
Ian Titulaer +2 more
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Vascular normalization confers an endothelial immune suppressive gene expression profile
Molecular Oncology, EarlyView.We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley +1 more source
Is there a case for establishing a multi-Centre Masters Programme in Public Health across Kent, Surrey and Sussex? A feasibility study [PDF]
, 2004 This study, which was commissioned by the Kent, Surrey and Sussex Workforce Development Confederation, assesses the feasibility of establishing a multi-centred modular masters programme in public health.
Cornish, Yvonne
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Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Human Resources for HealthBackground Health workforce projection models are integral components of a robust healthcare system. This research aims to review recent advancements in methodology and approaches for health workforce projection models and proposes a set of good practice
John Tayu Lee +8 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source