Results 121 to 130 of about 11,242,010 (306)

Healthy Ageing

, 2018
The essence of accessibility in combination with a family care approach was ...
Christine Stephens, Mary Breheny
  +4 more sources

Herbal medicine and non-hospital utilisation in Malaysia during the COVID-19 pandemic

Discover Public Health
Background COVID-19 is an infectious disease that led to over 3 million deaths globally during the pandemic. Herbal medicine (HM) has become popular during the COVID-19 pandemic; however, it is unclear whether this reliance on HM has affected ...
Ashwini Reddy Ravi Chander, Teik Guan Tan, Rahela Zaman, Eugenie Sin Sing Tan, Normina Ahmad Bustami, Chung Keat Tan   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Single G-quadruplex-based fluorescence method for the uracil-DNA glycosylase inhibitor screening

Heliyon
Uracil-DNA glycosylase (UDG) plays a pivotal role in the base repair system. Through bioinformatics, we found that the expression of the UDG enzyme in many cancer cells is increased, and its high expression is not conducive to the prognosis of lung ...
Pansong Zhang, Fangfang He, Xin Chang
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

The Effects of the MONOZUKURI Program on Executive Function Among Community‐Dwelling Older Adults: A Randomized Controlled Trial

Brain and Behavior
Introduction This study aimed to examine the effect of the MONOZUKURI program, a cognitive intervention related to creative activities (handicrafts and creative cooking), on cognitive function in community‐dwelling older adults.
Ai Iizuka, Susumu Ogawa, Daisuke Cho, Kyoko Fujihira, Yan Li, Kenichiro Sato, Keigo Hinakura, Kimi Estela Kobayashi‐Cuya, Hiroyuki Suzuki   +8 more
doaj   +1 more source

Simvastatin-Induced Insulin Resistance May Be Linked to Decreased Lipid Uptake and Lipid Synthesis in Human Skeletal Muscle: the LIFESTAT Study

Journal of Diabetes Research, 2018
Background. A prevalent side-effect of simvastatin is attenuated glucose homeostasis. The underlying mechanism is unknown, but impaired lipid metabolism may provide the link.
Steen Larsen, Andreas Vigelsø, Sune Dandanell, Clara Prats, Flemming Dela, Jørn Wulff Helge   +5 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline

Communications Medicine
Background Physio-cognitive decline (PCD) represents a dual impairment of mobility and cognitive function in aging populations, significantly increasing risks of disability, dementia, and mortality.
Yi-Long Huang, Wei-Ju Chang, Chao-Hsiung Lin, Shu Zhang, Yukiko Nishita, Rei Otsuka, Wei-Ju Lee, Chih-Kuang Liang, Ming-Yueh Chou, Li-Ning Peng, Hidenori Arai, Luigi Ferrucci, Liang-Kung Chen   +12 more
doaj   +1 more source