Results 121 to 130 of about 933,857 (297)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

The Effects of the MONOZUKURI Program on Executive Function Among Community‐Dwelling Older Adults: A Randomized Controlled Trial

Brain and Behavior
Introduction This study aimed to examine the effect of the MONOZUKURI program, a cognitive intervention related to creative activities (handicrafts and creative cooking), on cognitive function in community‐dwelling older adults.
Ai Iizuka, Susumu Ogawa, Daisuke Cho, Kyoko Fujihira, Yan Li, Kenichiro Sato, Keigo Hinakura, Kimi Estela Kobayashi‐Cuya, Hiroyuki Suzuki   +8 more
doaj   +1 more source

Single G-quadruplex-based fluorescence method for the uracil-DNA glycosylase inhibitor screening

Heliyon
Uracil-DNA glycosylase (UDG) plays a pivotal role in the base repair system. Through bioinformatics, we found that the expression of the UDG enzyme in many cancer cells is increased, and its high expression is not conducive to the prognosis of lung ...
Pansong Zhang, Fangfang He, Xin Chang
doaj   +1 more source

Population Aging: Facts, Challenges, and Responses [PDF]

The world’s population is growing older, leading us into uncharted demographic waters. There will be higher absolute numbers of elderly people, a larger share of elderly, longer healthy life expectancies, and relatively fewer numbers of working-age ...
Atsushi Seike, Axel Boersch-Supan, David E. Bloom, Patrick McGee   +3 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Data from multi-national aging cohorts show dysregulated metabolic pathways in people with physio-cognitive decline

Communications Medicine
Background Physio-cognitive decline (PCD) represents a dual impairment of mobility and cognitive function in aging populations, significantly increasing risks of disability, dementia, and mortality.
Yi-Long Huang, Wei-Ju Chang, Chao-Hsiung Lin, Shu Zhang, Yukiko Nishita, Rei Otsuka, Wei-Ju Lee, Chih-Kuang Liang, Ming-Yueh Chou, Li-Ning Peng, Hidenori Arai, Luigi Ferrucci, Liang-Kung Chen   +12 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Gender Differences in the Influence of Economic, Lifestyle, and Psychosocial Factors on Later-life Health [PDF]

This paper examines the differential impact of social forces on the health of men and women aged 65+ using data from the 1994-1995 National Population Health Survey.
Ellen Gee, Steven G. Prus
core  

A software for aging faces applied to ancient marble busts [PDF]

, 2013
The study and development of software able to show the effect of aging of faces is one of the tasks of face recognition technologies. Some software solutions are used for investigations, some others to show the effects of drugs on healthy appearance ...
Sparavigna, Amelia Carolina
core   +1 more source