Results 101 to 110 of about 1,887,079 (308)

Identifying patient subgroups in MASLD and MASH-associated fibrosis: molecular profiles and implications for drug development

Scientific Reports
The incidence of MASLD and MASH-associated fibrosis is rapidly increasing worldwide. Drug therapy is hampered by large patient variability and partial representation of human MASH fibrosis in preclinical models.
Manuel A. González Hernández, Lars Verschuren, Martien P.M. Caspers, Martine C. Morrison, Jennifer Venhorst, Jelle T. van den Berg, Beatrice Coornaert, Roeland Hanemaaijer, Gerard J. P. van Westen   +8 more
doaj   +1 more source

Making the Case and Getting Underway: A Funder Toolkit to Support Healthy People in Healthy Places [PDF]

, 2009
This toolkit was created as part of the Health Eating Active Living Convergence Partnership (www.convergencepartnership.org) to help funders create multi-field environmental change strategies to enhance healthy eating and active ...
Amy Main Morganstern, Kris Putnam-Walkerly   +1 more
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Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Mental health: promoting healthy minds for living and learning [PDF]

The Victorian government is committed to building the capacity of schools and early childhood education and care settings to support the mental health and wellbeing of children and young people.  This website has been designed to support staff in

core  

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Hubungan antara Perilaku Hidup Bersih dan Sehat (PHBS) Rumah Tangga dan Status Kesehatan dengan Kejadian Gizi Kurang pada Balita di Kelurahan Bulakan Kabupaten Sukoharjo [PDF]

, 2015
The issue of undernutrition is one problem of malnutrition in need of special attention. Prevention and tackling malnutrition not only improve aspects of food but also the child, availability of clean water, health and the environment.
, Ir. Listyani Hidayati, M.Kes, , Luluk Ria Rakhma, S.Gz., M.Gizi, Munawaroh, Arifatul   +2 more
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Monitoring and evaluating an implementation strategy aimed at improving interprofessional collaboration in community-based fall prevention: a mixed-methods study

Implementation Science Communications
Background Interprofessional collaboration (IPC) among health and social care providers is crucial to effectively implement community-based fall prevention.
Meike C. van Scherpenseel, Lidia J. van Veenendaal, Di-Janne J. A. Barten, Cindy Veenhof, Marielle H. Emmelot-Vonk, Saskia J. te Velde   +5 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A qualitative study of young workers’ experience of the psychosocial work environment and how this affects their mental health

BMC Public Health
Background The evidence base for the relationship between psychosocial work factors and mental health focuses primarily on the general working population but little is known about young workers.
Malte van Veen, Roosmarijn MC Schelvis, Paulien M Bongers, Karen M Oude Hengel, Cécile RL Boot   +4 more
doaj   +1 more source