Results 171 to 180 of about 609,352 (314)

The Feasibility of a Co-Designed Online Healthy Living Intervention for Cancer Survivors: Valuable Content, But Limited Engagement. [PDF]

Psychooncology
Leske M, Koczwara B, Blunt J, Short CE, Daly A, Morris JN, Degner J, Beatty L.   +7 more
europepmc   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Quadruple Burden of Young Child Malnutrition in the Children's Healthy Living Program, United States-Affiliated Pacific. [PDF]

J Nutr
Novotny R, Dela Cruz R, Hammond K, Yamanaka AB, Wilkens LR, Shallcross L, Coleman P, Aflague TF, Fleming T, Deenik J, Butel J.   +10 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Usage and Exposure to Content of the NHS Healthy Living Program for People With Type 2 Diabetes: Retrospective Observational Cohort Study. [PDF]

J Med Internet Res
Marsden AM, Hawkes RE, Benton JS, French DP, Cotterill S.   +4 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Cornell Institute for Healthy Futures Takes Holistic View of Health

, 2016
To address modern health care challenges, the College of Human Ecology and the School of Hotel Administration (SHA) have formed the Cornell Institute for Healthy Futures (CIHF), believed to be the world’s first academic center to combine hospitality ...
Cornell Institute for Healthy Futures
core  

Toward sustainable healthy living in South Africa: the asymmetric effects of clean energy, natural resources and institutional quality. [PDF]

Front Public Health
Iorember PT, van Niekerk A.
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Healthy living environment, healthy people

, 2017
In opdracht van de minister van Infrastructuur en Milieu (IenM) worden de Nationale Omgevingsagenda (NOA) en Nationale Omgevingsvisie (NOVI) ontwikkeld.
Staatsen BAM, van Alphen Th, Broek I van den, Kruize H, Houweling DA   +4 more
core