Is there an unmet medical need for improved hearing restoration? [PDF]
EMBO Molecular Medicine, 2022 Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain
Bettina Julia Wolf +7 more
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Towards the optical cochlear implant: optogenetic approaches for hearing restoration [PDF]
EMBO Molecular Medicine, 2020 Cochlear implants (CIs) are considered the most successful neuroprosthesis as they enable speech comprehension in the majority of half a million CI users suffering from sensorineural hearing loss.
Alexander Dieter +2 more
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Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies [PDF]
Brain Sciences, 2020 Most adults who acquire hearing loss find it to be a disability that is poorly corrected by current prosthetics. This gap drives current research in cochlear mechanosensory hair cell regeneration and in hearing restoration.
Patricia M. White
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The Myc Road to Hearing Restoration [PDF]
Cells, 2012 Current treatments for hearing loss, the most common neurosensory disorder, do not restore perfect hearing. Regeneration of lost organ of Corti hair cells through forced cell cycle re-entry of supporting cells or through manipulation of stem cells, both ...
Bernd Fritzsch, Benjamin Kopecky
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Noise and Health, 2012 Hearing impaired and normal hearing individuals were compared in two within-participant office noise conditions (high noise: 60 L Aeq and low noise: 30 L Aeq ).
Helena Jahncke, Niklas Halin
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Recent Advancements in the Regeneration of Auditory Hair Cells and Hearing Restoration [PDF]
Frontiers in Molecular Neuroscience, 2017 Neurosensory responses of hearing and balance are mediated by receptors in specialized neuroepithelial sensory cells. Any disruption of the biochemical and molecular pathways that facilitate these responses can result in severe deficits, including ...
Rahul Mittal +9 more
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The Long-Term Stability of Fat-Graft Myringoplasty in the Closure of Tympanic Membrane Perforations and Hearing Restoration. [PDF]
ORL J Otorhinolaryngol Relat Spec, 2021 Han JS +4 more
europepmc +2 more sources
Graded optogenetic activation of the auditory pathway for hearing restoration [PDF]
, 2022 Mittring A, Moser T, Huet A.
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Resilience and vulnerability of neural speech tracking after hearing restoration [PDF]
Communications BiologyThe role of early auditory experience in the development of neural speech tracking remains an open question. To address this issue, we measured neural speech tracking in children with or without functional hearing during their first year of life after ...
Alessandra Federici +12 more
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Optogenetic Infection and Optical Stimulation: A Study on Auditory Responses in Guinea Pig Cochlear Neurons [PDF]
Journal of OtologyObjectiveThis study aims to establish an economically viable and easily accessible adult animal model for optogenetic activation of auditory neurons using adeno-associated viruses (AAVs) carrying ChR2(H134R) to explore the potential of cochlear ...
Chen Liu, Ning Yu
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