Results 21 to 30 of about 13,726 (223)

Rapid cochlear gene therapy in adult deaf mice: Vglut3 rescue via AAV8 achieves day-1 hearing restoration [PDF]

Mol Ther Methods Clin Dev
Zhang T, Zhai R, Liu M, Xu H, Wang L, Tang W, Chen B, Zhao X.   +7 more
europepmc   +2 more sources

Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model

Frontiers in Molecular Neuroscience, 2021
Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants.
David Oestreicher, David Oestreicher, Maria Magdalena Picher, Vladan Rankovic, Vladan Rankovic, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic   +12 more
doaj   +1 more source

Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants

Computational and Structural Biotechnology Journal, 2022
When hearing fails, electrical cochlear implants (eCIs) partially restore hearing by direct stimulation of spiral ganglion neurons (SGNs). As light can be better confined in space than electrical current, optical CIs (oCIs) provide more spectral ...
Lakshay Khurana, Daniel Keppeler, Lukasz Jablonski, Tobias Moser   +3 more
doaj   +1 more source

Which Came First, Age-Related Hearing Loss with Tinnitus or Cognitive Impairment? What are the Potential Pathways?

Journal of Integrative Neuroscience, 2023
Research on the causal relationship between age-related hearing loss (ARHL) and/or tinnitus and dementia is an important and fast-moving field. In this opinion paper, the up-to-date evidence and potential mechanisms for the bidirectional relationship are
Qingwei Ruan, Bing Chen, Francesco Panza
doaj   +1 more source

Cochlear implantation performance outcomes in patients over 80 years old

Laryngoscope Investigative Otolaryngology, 2022
Objective To examine device datalogging characteristics and postoperative performance in the very elderly CI users. Methods Retrospective chart review of postoperative speech recognition outcomes and datalogging characteristics in patients older than 80 ...
Helena Wichova, Dawna Mills, Sarah Beatty, Kevin Peng, Mia Miller   +4 more
doaj   +1 more source

Conversations in Cochlear Implantation: The Inner Ear Therapy of Today

Biomolecules, 2022
As biomolecular approaches for hearing restoration in profound sensorineural hearing loss evolve, they will be applied in conjunction with or instead of cochlear implants. An understanding of the current state-of-the-art of this technology, including its
Grant Rauterkus, Anne K. Maxwell, Jacob B. Kahane, Jennifer J. Lentz, Moises A. Arriaga   +4 more
doaj   +1 more source

Understanding and treating paediatric hearing impairment

EBioMedicine, 2021
Sensorineural hearing impairment is the most frequent form of hearing impairment affecting 1–2 in 1000 newborns and another 1 in 1000 adolescents. More than 50% of congenital hearing impairment is of genetic origin and some forms of monogenic deafness ...
Christian Wrobel, Maria-Patapia Zafeiriou, Tobias Moser   +2 more
doaj   +1 more source

Inner ear therapeutics and the war on hearing loss: systemic barriers to success

Frontiers in Neuroscience, 2023
Despite over 20 years of effort in academic research centers, start-up companies, and established pharmaceutical companies, there are no FDA-approved inner ear therapeutics for treatment of sensorineural hearing loss.
Nicole T. Jiam, Steven D. Rauch
doaj   +1 more source

Developing Fast, Red-Light Optogenetic Stimulation of Spiral Ganglion Neurons for Future Optical Cochlear Implants

Frontiers in Molecular Neuroscience, 2021
Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical CIs (oCIs).
Antoine Tarquin Huet, Antoine Tarquin Huet, Tobias Dombrowski, Tobias Dombrowski, Tobias Dombrowski, Vladan Rankovic, Vladan Rankovic, Vladan Rankovic, Anupriya Thirumalai, Anupriya Thirumalai, Tobias Moser, Tobias Moser, Tobias Moser, Tobias Moser   +13 more
doaj   +1 more source

Effect of COVID-19 on Individuals with Hearing Impairment in India [PDF]

Journal of Clinical and Diagnostic Research, 2020
COVID-19 has proven to be pandemic and affecting the day to day life of normal individuals. However, individuals with disability, especially with hearing impairment face even more difficulty.
Abishek Umashankar, Prashanth Prabhu
doaj   +1 more source