Results 101 to 110 of about 181,509 (297)

Indications for Lung Transplantation and Patient Selection

Journal of Chest Surgery, 2022
Globally, thousands of patients undergo lung transplantation owing to end-stage lung disease each year. As lung transplantation evolves, recommendations and indications are constantly being updated. In 2021, the International Society for Heart and Lung
Joohyung Son, Changwon Shin
doaj   +1 more source

Origin of lymph node-derived lymphocytes in human hepatic allografts [PDF]

, 1989
Hepatic allograft-derived lymph nodes were examined in the post-transplant period on order to determine the origin of lymphocytes and structural elements of the lymph node.
Chen, K, Demetris, AJ, Duquesnoy, RJ, Fung, JJ, Markus, B, Marrarri, M, Starzl, TE, Zeevi, A   +7 more
core   +1 more source

Non-infectious pulmonary complications of hematopoietic stem cell transplantation [PDF]

, 2014
Noninfectious pulmonary complications of hematopoietic stem cell transplant are currently more prevalent than infectious complications. Unfortunately, the pathophysiology basis is not completely understood.
Baloglu, Orkun, McArthur, Jennifer, Rowan, Courtney   +2 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

An early nationwide analysis on the continuous distribution of lung-involved multiorgan transplantationCentral MessagePerspective

JTCVS Open
Background: The impact of continuous distribution on allocation of multiorgan transplantation (MOT) involving lungs remains unexplored. Here we characterize how continuous distribution has affected lung-involved MOT. Methods: We conducted a retrospective
Haoran Jiang, MS, Isaac S. Alderete, MD, MHS, Alexandria L. Soto, MA, Matthew Libre, BA, Samantha E. Halpern, MD, MHS, Oliver K. Jawitz, MD, MHS, Joshua A. Rushakoff, MD, MPP, Benjamin R. Helmold, BA, Kunal J. Patel, MD, PhD, Hiroshi Date, MD, PhD, Jacob Klapper, MD, MHS, Matthew G. Hartwig, MD, MHS   +11 more
doaj   +1 more source

Suppressor of IKKɛ is an essential negative regulator of pathological cardiac hypertrophy

Nature Communications, 2016
Although pathological cardiac hypertrophy represents a leading cause of morbidity and mortality worldwide, our understanding of the molecular mechanisms underlying this disease is still poor.
Ke-Qiong Deng, Aibing Wang, Yan-Xiao Ji, Xiao-Jing Zhang, Jing Fang, Yan Zhang, Peng Zhang, Xi Jiang, Lu Gao, Xue-Yong Zhu, Yichao Zhao, Lingchen Gao, Qinglin Yang, Xue-Hai Zhu, Xiang Wei, Jun Pu, Hongliang Li   +16 more
doaj   +1 more source

Laparoscopic Delivery of a MnO2‐P‐ICG Patch for Photodynamic Therapy and NK Cell‐Driven Immunotherapy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
This study proposes a flexible MnO2‐P‐ICG nanofiber patch for laparoscopic treatment of liver tumors. The patch alleviates tumor hypoxia and induces photodynamic therapy (PDT) triggered immunogenic cell death, thereby activating the cGAS‐STING pathway and, in synergy with pachymaran, promoting NK cell–mediated innate immunity. This synergistic strategy
Jie Lin, Haoqi Pan, Ke Wu, Junjie Nan, Jinyao Dai, Yushun Chang, Hao Shen, Qingxuan Ye, Haowen Lu, Yuxuan Shen, Boqiang Liu, Ming Wu, Jicheng Yu, Xiujun Cai, Dong Cen   +14 more
wiley   +1 more source

Longitudinal impact of demographic and clinical variables on Health-Related Quality of Life in Cystic Fibrosis [PDF]

, 2015
Objectives: The insights that people with cystic fibrosis have concerning their health are important given that aspects of health-related quality of life (HRQoL) are independent predictors of survival and a decrease in lung function is associated with a ...
A-Rahman, Abbott, Abbott, Abbott, Arrington-Sanders, Bradley, Bradley, Dill, Duff, Feltrim, Fitzmaurice, Gee, Gee, Gee, Goldbeck, Kreft, Kugler, Lowton, Quattrucci, Quittner, Rasbash, Rodgers, Sawicki, Sawicki, Sawicki, Schmitz, Smeritschnig, Spahr, Staab, Taylor, Tierney, Ullrich, Wahl, Walters   +33 more
core   +2 more sources

Bioorthogonal Fluorogenic Reporters for Noninvasive Imaging and Urinalysis of Immunotherapeutic Response in Renal Cell Carcinoma

Advanced Science, EarlyView.
This study reported renal‐clearable bio‐orthogonal near‐infrared fluorogenic probes (BGRs) that specifically imaging and urinalysis of granzyme B for dynamic evaluation of RCC immunotherapy. BGRs not only differentiate immunotherapeutic responses in orthotopic RCC mice, but also enable sensitive optical urinalysis of granzyme B in clinical specimens ...
Xingyue Yang, Baoshuai Liang, Liangmin Fu, Weiliang Deng, Yuyan Jiang, Weiping Xu, Jinwei Chen, Ya Zhou, Ke Wu, Jiaguo Huang   +9 more
wiley   +1 more source

Overexpression of hypoxia-inducible factor 1 alpha improves immunomodulation by dental mesenchymal stem cells

Stem Cell Research & Therapy, 2017
Background Human dental mesenchymal stem cells (MSCs) are considered as highly accessible and attractive MSCs for use in regenerative medicine, yet some of their features are not as well characterized as other MSCs.
Victor G. Martinez, Imelda Ontoria-Oviedo, Carolina P. Ricardo, Sian E. Harding, Rosa Sacedon, Alberto Varas, Agustin Zapata, Pilar Sepulveda, Angeles Vicente   +8 more
doaj   +1 more source