Results 111 to 120 of about 181,509 (297)

Usefulness of gene expression profiling of bronchoalveolar lavage cells in acute lung allograft rejection. [PDF]

, 2019
BackgroundChronic lung allograft dysfunction (CLAD) is the main limitation to long-term survival after lung transplantation. Because effective therapies are lacking, early identification and mitigation of risk factors is a pragmatic approach to improve ...
Belperio, John A, Budev, Marie, Danziger-Isakov, Lara A, Li, Xinmin, Palchevskiy, Vyacheslav, Palmer, Scott, Patel, Naman, Reynolds, John, Ross, David J, Shah, Pali D, Singer, Lianne G, Sweet, Stuart C, Wang, Xiaoyan, Weigt, S Samuel   +13 more
core   +1 more source

Kidney after nonrenal transplantation-the impact of alemtuzumab induction [PDF]

, 2009
BACKGROUND.: Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population.
Amit Basu, Calne, Claire Morgan, Deanna Blisard, Demetrius Ellis, Eghtesad, Geoffrey Kurland, George Mazariegos, Henkie P. Tan, Igor Dvorchik, J Wallis Marsh, Jerry McCauley, Kareem Abu-Elmagd, Kenneth R. McCurry, Kirk, Knechtle, Ojo, Parmjeet S. Randhawa, Ron Shapiro, Shapiro, Shapiro, Shapiro, Steven Webber, Stuart, Tan, Thomas E. Starzl, Vivek Sharma, Waldmann   +27 more
core   +1 more source

Smartly Assembled near‐Micron RF‐Responsive Agents Bridge Transarterial Embolization and Immunothermal Potentiation

Advanced Science, EarlyView.
ABSTRACT Hepatocellular carcinoma (HCC) remains a significant clinical challenge due to the limited efficacy of conventional treatments like surgery, radiofrequency ablation (RFA), and transarterial embolization (TAE). Here, we develop an innovative TAE and immunothermal therapy strategy based on smartly assembled near‐micron layered double hydroxide ...
Qitao Hu, Junkang Ding, Lingxiao Zhang, Zhou Tian, Cheng Zeng, Shaomin Zou, Wenjing Zhang, Tangye Zeng, Zhencang Gao, Zhouyi Sun, Gang Liu, Weiyu Chen, Zhe Tang   +12 more
wiley   +1 more source

Outcomes and predictors of early infection after heart transplantation [PDF]

, 2018
Background: Limited data exist on the incidence and outcome of early infection after orthotopic heart transplantation (OHT). The purpose of this study was to describe characteristics and outcomes of OHT recipients with an early infection and to identify ...
Balsara, Keki, Itoh, Akinobu, Micek, Scott, Shultes, Kendall C, Shuster, Jerrica E, Tellor, Bethany R, Vader, Justin M   +6 more
core   +2 more sources

Synchronization‐Dissipation in the Cardiorespiratory System

Advanced Science, EarlyView.
By modeling central nervous coupling and viscoelastic interactions in the cardiorespiratory system we show that synchronization produces a 10% gain in cardiac efficiency in humans. It is surmised that respiratory sinus arrhythmia improves cardiac pumping efficiency by reducing dynamic stress and power dissipation in the pulmonary vasculature.
Joshua R. Border, Alain Nogaret, Andrew Lefevre, Vishal Jain   +3 more
wiley   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Primary graft dysfunction prevention strategies in the perioperative period

JHLT Open
Background: Primary graft dysfunction (PGD) remains a leading cause of early morbidity and mortality after heart and lung transplantation. It results from a multifactorial process involving ischemia–reperfusion injury, inflammatory and immune responses ...
Jérémie Guillemin, MD, Michael Cutrone, DO, Suraj Yalamuri, MD, Monica Arndt, MD, Adrien Bouglé, MD, PhD, Sharon L. McCartney, MD, FASE   +5 more
doaj   +1 more source

Single-Kidney Transplant on VA-ECMO While Recovering from Post-Heart-Transplant Graft Failure

Case Reports in Critical Care, 2018
Although no consensus exists on whether extracorporeal membrane oxygenation (ECMO) support is an indication for solid-organ transplantation other than heart and lung, this practice continues to be limited.
Gabriel Prada, Anjali Agarwal, Jose L. Diaz-Gomez, Robert A. Ratzlaff   +3 more
doaj   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

Advanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang, Xin He, Hao Huang, Rong Lu, Xin Lv, Shenglan Li, Sijue Zou, Jiawei Cheng, Yiwei Xiong, Zhenghao Deng, Qiongjing Yuan, Yanyun Xie, Ling Huang, Jiaxi Pu, Shao Liu, Qianbin Li, Jie Meng, Huixiang Yang, Lijian Tao, Zhangzhe Peng   +19 more
wiley   +1 more source

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

Advanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai, Huan Yu, Zihan Ni, Kan Chen, I‐Chen Tsai, Zeyu Bao, Shuo Sun, Weichang Li, Yunhua Chen, Qiong Xu   +9 more
wiley   +1 more source