Results 91 to 100 of about 181,509 (297)

Improvement of lung preservation - From experiment to clinical practice [PDF]

, 2002
Background. Reperfusion injury represents a severe early complication following lung transplantation. Among the pathogenetic factors, the high potassium content of Euro-Collins(R) solution is discussed.
Bittmann, I., Fürst, H., Hatz, Rudolf A., Kellner, B., Müller, Ch., Reichart, B., Schelling, G., Schildberg, Friedrich Wilhelm   +7 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Pediatric lung transplantation: The years 1985 to 1992 and the clinical trial of FK 506 [PDF]

, 1993
The application of lung transplantation to the pediatric population was a natural extension of the success realized in our adult transplantation program, which began in 1982. Twenty pediatric patients (age range 3 to 18 years) have had heart-lung (n = 11)
Armitage, Armitage, Baldwin, Bartley P. Griffith, Billingham, Bisson, Cooper, Frederick J. Fricker, Geoffrey Kurland, Griffith, Hardesty, John M. Armitage, Keenan, Krien, Kusne, Marian Michaels, Patterson, Robert L. Hardesty, Ronald Jaffe, Rosendale, Samuel A. Yousem, Shigeki Morita, Tamaura, Thomas E. Starzl, Yousem, Zeevi, Zenati, Zenati   +27 more
core   +1 more source

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

Advanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng, Bingzhi Chen, Yu Xu, Xin Xu, Bingtao Hu, Tongbo Li, Dingxin Zhang, Baoshuai Bai, Chen Liu, Wanlong Xu, Le Li, Wencan Zhang, Haipeng Si   +12 more
wiley   +1 more source

2015 ESC/ERS GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF PULMONARY HYPERTENSION

Российский кардиологический журнал, 2016
The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS)Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC ...
Nazzareno Galiè, Marc Humbert, Jean-Luc Vachiery, Simon Gibbs, Irene Lang, Adam Torbicki, Gérald Simonneau, Andrew Peacock, Anton Vonk Noordegraaf, Maurice Beghetti, Ardeschir Ghofrani, Miguel Angel Gomez Sanchez, Georg Hansmann, Walter Klepetko, Patrizio Lancellotti, Marco Matucci, Theresa McDonagh, Luc A. Pierard, Pedro T. Trindade, Maurizio Zompatori, Marius Hoeper   +20 more
doaj   +1 more source

Unraveling the Role of Allo-Antibodies and Transplant Injury. [PDF]

, 2016
Alloimmunity driving rejection in the context of solid organ transplantation can be grossly divided into mechanisms predominantly driven by either T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR), though the co-existence of both ...
Matsuda, Yoshiko, Sarwal, Minnie M
core   +2 more sources

SAA/FPR2 Signaling Between Pericentral Hepatocytes and Macrophages Exacerbates Zonated Liver Transplant Injury

Advanced Science, EarlyView.
After liver transplantation, ischemia‐reperfusion injury is more severe in pericentral regions. Multiomic analyses of human grafts and mouse models identify FOXO1 activation in pericentral hepatocytes as an upstream driver of SAA secretion. SAA recruits and activates FPR2+ macrophages, amplifying local inflammation. Amilo‐5MER inhibits SAA bioactivity,
Feng Zhang, Rong Li, Tingting Wang, Jianhao Zhang, Zhengqi Wu, Qiang You, Xuying Liu, Cuicui Xiao, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Jia Yao, Jun Zheng, Yingcai Zhang, Hua Li, Shuhong Yi, Yang Yang, Qi Zhang, Xiaofeng Yuan, Yasong Liu   +19 more
wiley   +1 more source

Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus

Journal for ImmunoTherapy of Cancer
Background We discovered a novel human endogenous retrovirus (CT-RCC HERV-E) that was selectively expressed in most clear cell renal cell carcinomas (ccRCC) and served as a source of antigens for T cell-mediated killing. Here, we described the cloning of
Long Chen, David F Stroncek, Gang Zeng, Steven Highfill, Robert Reger, Stefan Barisic, Elena Cherkasova, Elizabeth M Brahmbhatt, Timothy T Spear, Ujjawal Savani, Stephanie Pierre, Gina M Scurti, Muna Igboko, Rosa Nadal, Gordon Parry, Annika V Dalheim, Michael I Nishimura, Richard W Childs   +17 more
doaj   +1 more source

Cell migration and chimerism after whole‐organ transplantation: The basis of graft acceptance [PDF]

, 1993
Improvements in the prevention or control of rejection of the kidney and liver have been largely interchangeable ( 1 , 2 ) and then applicable, with very little modification, to thoracic and other organs.
Demetris, AJ, Fung, JJ, Ildstad, S, Kocova, M, Murase, N, Nalesnik, M, Ramos, H, Ricordi, C, Rudert, WA, Starzl, TE, Todo, S, Trucco, M, Tzakis, A, Zeevi, A   +13 more
core   +1 more source

Liver‐Targeted Gallium‐Polyphenol Network by Disrupting the ROS/NETs/PANoptosis Axis for Precision Acute Liver Injury Therapy

Advanced Science, EarlyView.
ABSTRACT Acute liver injury (ALI), driven by diverse insults such as drug toxicity and ischemia‐reperfusion, poses a high mortality risk and lacks targeted therapies. While reactive oxygen species (ROS), neutrophil extracellular traps (NETs), and a coordinated cell death pathway PANoptosis have been implicated, their interplay as a unified pathogenic ...
Xiaopeng Cai, Jian He, Jingwen Deng, Ziwei Wang, Zhongshu Wu, Kaiyue Wang, Xiang Zheng, Zhenzhen Gao, Xi Ma, Shumei Wei, Xiangrong Hu, Yuan Ding, Weilin Wang, Min Zhou   +13 more
wiley   +1 more source