Results 71 to 80 of about 100,615 (218)

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

Global strategies to improve equitable access to heart and lung transplantation- ISHLT Consortium Report

JHLT Open
Background: Many inequities exist in the global access of heart and lung transplantation. Few studies have identified global strategies to implement equitable access to heart or lung transplantation.
Khadijah Breathett, MD, MS, Johanna Contreras, MD, MS, Sabra Lewsey, MD, MPH, Alessandra Agnese Grossi, PhD, Kyung-Hee Kim, MD, PhD, Ainur Akilzhanova, MD, PhD, Olawale Amubieya, MD, PhD, Nicholas Avdimiretz, MD, FRCPC, Abigail Boyle, MA, BSN, RN, Leanne Duhaney, MD, MPH, Cesar Guerrero, MD, Onyedika Ilonze, MD, MPH, Holly Keyt, MD, Jake Kleinmahon, MD, Juan Carlos Leoni Moreno, MD, Lorena Montes, MD, Matthew Montgomery, DO, MBA, MPH, Andrew Morley-Smith, MRCP, PhD, Franziska Olm, PhD, Jyotika Prasad, MD, Saule Rakhimova, MD, PhD, Leslie Seijo, MD, Luciano Potena, MD, PhD   +22 more
doaj   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Percutaneous implantation of self-expanding pulmonary valves: results from real-life experience of the Venus-P valve Registry of the Italian Society of Pediatric Cardiology (SICPED)

International Journal of Cardiology Congenital Heart Disease
Background: Self-expandable valves may have a significant impact on the feasibility of transcatheter treatments of RVOT dysfunction. Venus P valve is the first autoexpadable Valve that received CE mark in 2022.
M. Pilati, F.A. D'Aiello, M. Chessa, G. Santoro, A. Donti, E. Mariucci, C. Marrone, G. Annoni, G. Gaio, M. Rebonato, E. Piccinelli, M. Cheli, R. Formigari, G. Butera   +13 more
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Stem cell therapy targeting the right ventricle in pulmonary arterial hypertension: is it a potential avenue of therapy?

Pulmonary Circulation, 2018
Pulmonary arterial hypertension (PAH) is an incurable disease characterized by an increase in pulmonary arterial pressure due to pathological changes to the pulmonary vascular bed.
Fanny Loisel, Bastien Provost, François Haddad, Julien Guihaire, Myriam Amsallem, Bojan Vrtovec, Elie Fadel, Georges Uzan, Olaf Mercier   +8 more
doaj   +1 more source

Gut Microbiota‐Derived Indole‐3‐Propionic Acid Alleviates Diabetic Osteoporosis Through Nrf2‐Mediated Ferroptosis Suppression

Advanced Science, EarlyView.
Diabetes‐associated dysbiosis is accompanied by reduced Clostridium abundance, impaired microbial tryptophan metabolism, and lower circulating indole‐3‐propionic acid (IPA). Exogenous IPA improves trabecular microarchitecture and bone formation and restores Nrf2‐associated antioxidant signaling in bone marrow mesenchymal stem cells, limiting iron ...
Jinwu Bai, Qinyong You, Gao Si, Daole Hu, Ao Sun, Shilong Su, Ruideng Wang, Jixing Fan, Shan Gao, Tengjiao Zhu, Chun‐Li Song, Fang Zhou, Yang Lv   +12 more
wiley   +1 more source

Transcervical approach for left ventricular assist device outflow graft: A proof-of-concept implantation studyCentral Message

JTCVS Techniques, 2021
Fraser William Havern Sutherland, MA, MB, BChir, MD(Cantab), FRCS, George Gradinariu, MD, MRCS, Philip Curry, MB, BS, FRCS   +2 more
doaj   +1 more source

Clinical characteristics of hemodynamics and laboratory parameters of recipients during orthotopic heart transplantation

Український журнал клінічної хірургії
Objective. To study the clinical and laboratory characteristics of recipients during orthotopic heart transplantation according to intraoperative monitoring. Materials and methods.
M. M. Goncharenko
doaj   +1 more source