Results 81 to 90 of about 137,114 (301)

Chronic Pain One to Five Years after Heart Transplantation [PDF]

, 2020
PURPOSE: We know that pain has far-reaching detrimental effects across various life-domains and also affects health related quality of life after solid organ transplantation. However, the extent to which heart recipients experience chronic bodily pain in
Dalvindt, M., Nozhoor, S., Forsberg, A.,, Kisch, A.,, Kisch, A., Dalvindt, M.,, Nozhoor, S.,, Forsberg, A., Lund University.   +8 more
core   +1 more source

Biomimetic electromechanical stimulation to maintain adult myocardial slices in vitro

Nature Communications, 2019
Cultured adult cardiac tissue undergoes rapid dedifferentiation, which hinders chronic in vitro studies. Here the authors investigate biomimetic electromechanical stimulation of adult myocardial slices applying different preload conditions, identifying ...
Samuel A. Watson, James Duff, Ifigeneia Bardi, Magdalena Zabielska, Santosh S. Atanur, Richard J. Jabbour, André Simon, Alejandra Tomas, Ryszard T. Smolenski, Sian E. Harding, Filippo Perbellini, Cesare M. Terracciano   +11 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Survival benefit of lung transplantation in individuals with severe α(1)-anti-trypsin deficiency (PiZZ) and emphysema [PDF]

, 2011
BACKGROUND: The objective of lung transplantation (LTx) is to prolong life, but the survival benefit for patients with severe α(1)-anti-trypsin deficiency (PiZZ) and emphysema is still unclear.
Riise, Gerdt C, Nilsson, Peter,, Hansson, Lennart,, Piitulainen, Eeva,, Tanash, Hanan,, Lund University.   +5 more
core   +1 more source

Donor age and ischemic time in heart transplantation -implications for organ preservation [PDF]

The Organ Care System and Non-ischemic Heart Preservation methods have emerged as significant advancements in heart transplantation, designed to mitigate ischemic injury and extend preservation times. However, their high costs and logistical complexities
Metzsch, Carsten, Nilsson, Johan, Lund, Lars H., Stehlik, Josef, Lund, Lars H, Andersson, Bodil, Perez, Raquel, Jernryd, Victoria, Gustav Smith, J., Smith, J. Gustav,   +9 more
core   +3 more sources

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Fear of Graft Rejection after Heart Transplantation [PDF]

, 2020
PURPOSE: Perceived Threat of the Risk of Graft Rejection (PTRGR) is prominent in organ transplant recipients' lives. When asked about what they fear most, the commonest response is graft rejection. A reasonable assumption is that this perceived threat is
Dalvindt, M., Paulsson, A., Lennerling, A.,, Lennerling, A., Ragntoft, C.,, Forsberg, A.,, Paulsson, A.,, Dalvindt, M.,, Ragntoft, C., Forsberg, A., Lund University.   +10 more
core   +1 more source

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

Heart transplantation: its risks, the expectations, and cultural negotiations in Japan [PDF]

, 2012
PhDThe aim of this thesis is to facilitate an understanding of the experiences of Japanese heart transplant recipients in terms of how their identities are transformed.
Tomomatsu, Ikuko
core  

The impact of gastrointestinal dysmotility on the aerodigestive microbiome of pediatric lung transplant recipients [PDF]

, 2020
BACKGROUND:Delayed gastric emptying has been associated with increased graft rejection, althoughthe mechanism of this association is not known. This study aims to investigate the interrelationshipbetween delays in gastrointestinal motility and the ...
Lurie, Margot,, Rosen, Rachel, Lötstedt, Britta,, Boyer, Debra,, Kane, Madeline,, Setchell, Kenneth,, Lundeberg, Joakim,, Visner, Gary,, Narvaez-Rivas, Monica,, Alm, Eric,, Freiberger, Dawn,, DiFilippo, Courtney,   +11 more
core