Results 121 to 130 of about 185,979 (321)

Targeting the SOX9/TIMP1 Axis with iRGD‐Conjugated Nanoplatform Enhances Dendritic Cell Function and Photodynamic Immunotherapy in Gastric Cancer

Advanced Science, EarlyView.
This study identifies the SOX9/TIMP1 axis as a key regulator of immune evasion in gastric cancer. iRGD‐conjugated nanoparticles co‐delivering si‐SOX9, Ce6, and L‐Arg are developed to synergize with photodynamic therapy. The nanoplatform suppresses tumor growth, promotes dendritic cell maturation, and enhances CD8+ T‐cell activation, offering a ...
Banghua Zhong, Yijie Zhang, Honghu Wang, Lili Guo   +3 more
wiley   +1 more source

The medical management of patients with cystic fibrosis following heart-lung transplantation [PDF]

, 1993
BP Madden, K Kamalvand, CM Chan, A. Khaghani, ME Hodson, Magdi H. Yacoub   +5 more
openalex   +1 more source

FXYD3 Promotes Tumor Progression by Binding With IRF7 to Regulate JAK2/STAT5 Signaling in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
FXYD3 binds IRF7 via its 60–87aa domain, triggering a cGAS/STING‐mediated positive feedback loop amplified by type I interferon. This sustains JAK2/STAT5 activation, accelerating ICC progression. Targeting FXYD3 with siFXYD3@PEP suppresses tumors and enhances chemotherapy sensitivity. Abstract Intrahepatic cholangiocarcinoma (ICC) has a poor prognosis,
Yan Zhou, Xiaofeng Shen, Shuo Zhang, XiaoHong Pu, Zipeng Xu, Xiang Zhao, Wei Feng, Yuan Liang, Xingtao He, Aihua Yang, Yudong Qiu, Yihang Yuan, Chaobo Chen, Jun Chen   +13 more
wiley   +1 more source

Exacerbation of Pulmonary Fibrosis Following Single Lung Transplantation

Canadian Respiratory Journal, 2012
Acute exacerbations of interstitial lung disease present as clinical deteriorations, with progressive hypoxemia and parenchymal consolidation not related to infection, heart failure or thromboembolic disease.
Dawei Yang, Jennifer M Wilson, Chunxue Bai, John Yee, Pearce G Wilcox, Nasreen Khalil, Robert D Levy   +6 more
doaj   +1 more source

Obligatory tacrolimus formulation substitution in heart and lung transplant recipients: A national bioequivalence audit [PDF]

, 2015
Sarah Fitzsimons, Helen Gibbs, Cara A. Wasywich, Tanya McWilliams, Peter Ruygrok   +4 more
openalex   +1 more source

Impaired Humoral and Cellular Responses to COVID-19 Vaccine in Heart and Lung Transplant Recipients

, 2022
Vicky Gerovasili, Anand Shah, Aran Singanayagam, Peter M. George, Raymond Njafuh, Maria Prendecki, Martin Carby, Michelle Willicombe, Peter Kelleher, Anna Reed   +9 more
openalex   +1 more source

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Advanced Science, EarlyView.
This study reports early Piezo1 activation in bone marrow monocyte‐derived macrophages (MoMs) during myocardial infarction (MI), which governs the fate and function of recruited macrophages. The recruited MoMs with increased Piezo1 expression exhibit increased ferroptosis and defective efferocytosis, delayed clearance of dead cells and resolution of ...
Lu Peng, Yunlong Xia, Huishou Zhao, Yongzhen Guo, Xiaoming Xu, Xue Han, Shiyue Wang, Fengyue Ding, Quanchi Liu, Congye Li, Yuan He, Zhaoyi Luo, Qiaojuan Wang, Xing Zhang, Feng Gao, Yajing Wang, Yulin Li, Shengpeng Wang, Ling Tao, Wenjun Yan   +19 more
wiley   +1 more source

Transcervical approach for left ventricular assist device outflow graft: A proof-of-concept implantation studyCentral Message

JTCVS Techniques, 2021
Fraser William Havern Sutherland, MA, MB, BChir, MD(Cantab), FRCS, George Gradinariu, MD, MRCS, Philip Curry, MB, BS, FRCS   +2 more
doaj   +1 more source

Technical Aspects of Combined Heart-Lung Transplantation. [PDF]

J Chest Surg, 2022
Ju MH, Je HG.
europepmc   +1 more source

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source