Results 51 to 60 of about 159,878 (309)

Effect of HIV-1-related protein expression on cardiac and skeletal muscles from transgenic rats

AIDS Research and Therapy, 2008
Background Human immunodeficiency virus type 1 (HIV-1) infection and the consequent acquired immunodeficiency syndrome (AIDS) has protean manifestations, including muscle wasting and cardiomyopathy, which contribute to its high morbidity.
Guidot David M, Brown Lou, Ashikhmin Yaroslav I, Otis Jeffrey S   +3 more
doaj   +1 more source

Genetic grouping and geographic distribution of Piscine orthoreovirus-1 (PRV-1) in farmed Atlantic salmon in Norway

Veterinary Research, 2021
Piscine orthoreovirus-1 (PRV-1) is the causative agent of heart and skeletal muscle inflammation (HSMI) in farmed Atlantic salmon (Salmo salar). However, it has been shown that PRV-1 variants differ in their ability to induce HSMI.
Nina A. Vatne, Marit Stormoen, Morten Lund, Magnus Devold, Espen Rimstad, Øystein Wessel   +5 more
doaj   +1 more source

Skeletal muscle as an experimental model of choice to study tissue aging and rejuvenation. [PDF]

, 2020
Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellular matrix cause a decline in tissue ...
Conboy, Irina M, Conboy, Michael J, Etienne, Jessy, Liu, Chao, Skinner, Colin M   +4 more
core  

A recipe for myositis : nuclear factor κB and nuclear factor of activated T-cells transcription factor pathways spiced up by cytokines [PDF]

, 2017
Nuclear factor κB (NF-κB) is a well-known pro-inflammatory transcription factor that regulates the expression of the tissue’s immune-active components, which include cytokines, chemokines and adhesion molecules.
De Paepe, Boel
core   +3 more sources

Progress in diagnosis and treatment of dermatomyositis

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Dermatomyositis (DM) is characterized by skin lesions, skeletal muscle inflammation, and involvement of other organs. The pathogenesis of DM includes susceptibility genes, environmental stressors, immune and non⁃immune inducing mechanisms.
ZHANG Ya⁃jing, YUE Wei
doaj   +1 more source

Chronic Heart Failure is Associated with Elevated Skeletal Muscle Inflammation and Toll‐Like Receptor 4 Signaling

The FASEB Journal, 2012
Chronic heart failure (CHF) is associated with increased inflammation. As inflammation impairs skeletal muscle protein maintenance, elevated skeletal muscle inflammation may increase the risk of developing CHF‐associated cachexia. Elevated expression and activation of the innate immune receptor, toll‐like receptor 4 (TLR4) may contribute to skeletal ...
Kyle L Timmerman, Jeremiah N West, Melissa M Markofski, Shaheen Dhanani, Blake B Rasmussen, Kashyap B Ckoksi, N Alejandro Barbagelata, Elena Volpi   +7 more
openaire   +1 more source

Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe significance of brain angiotensin II in Alzheimer disease (AD) is unclear. Methods and ResultsTo examine the role of brain angiotensin II in AD, intracerebroventricular angiotensin II infusion was performed on 5XFAD mice, a mouse model of ...
Koki Takane, Yu Hasegawa, Bowen Lin, Nobutaka Koibuchi, Cheng Cao, Takashi Yokoo, Shokei Kim‐Mitsuyama   +6 more
doaj   +1 more source

Heart and neural crest derivative 2‐induced preservation of sympathetic neurons attenuates sarcopenia with aging

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Sarcopenia, or age‐dependent decline in muscle force and power, impairs mobility, increasing the risk of falls, institutionalization, co‐morbidity, and premature death.
Anna Carolina Zaia Rodrigues, Zhong‐Min Wang, María Laura Messi, Henry Jacob Bonilla, Liang Liu, Willard M. Freeman, Osvaldo Delbono   +6 more
doaj   +1 more source

"Of Mice and Measures": A Project to Improve How We Advance Duchenne Muscular Dystrophy Therapies to the Clinic [PDF]

, 2018
A new line of dystrophic mdx mice on the DBA/2J (D2) background has emerged as a candidate to study the efficacy of therapeutic approaches for Duchenne muscular dystrophy (DMD). These mice harbor genetic polymorphisms that appear to increase the severity
Aartsma-Rus, A., Bogdanik, L, Davies, K, De Luca, A, Demonbruen, Ar, Duan, D, Elsey, D, Fukada, Si, Girgenrath, M, Gonzalez, Jp, Gordish-Dressman, H, Grounds, Md, Heydemann, A, Kreibich, A, Lutz, C, Nagaraju, K, Nichols, A, Partridge, T, Passini, M, Pazze, Ld, Sanarica, F, Schnell, Fj, Spencer, M, Spurney, C, van Putten, M, Wells, Dj, Willmann, R, Yokota, T, Young, Cs, Zhong, Z   +29 more
core   +3 more sources

Skeletal muscle atrophy in heart failure with diabetes: from molecular mechanisms to clinical evidence

ESC Heart Failure, 2021
Two highly prevalent and growing global diseases impacted by skeletal muscle atrophy are chronic heart failure (HF) and type 2 diabetes mellitus (DM). The presence of either condition increases the likelihood of developing the other, with recent studies ...
Nathanael Wood, Sam Straw, Mattia Scalabrin, Lee D. Roberts, Klaus K. Witte, Thomas Scott Bowen   +5 more
doaj   +1 more source