Results 51 to 60 of about 82,439 (260)

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Myocardial inflammation in Duchenne Muscular Dystrophy as a precipitating factor for heart failure: a prospective study

BMC Neurology, 2010
Background In patients with Duchenne Muscular Dystrophy (DMD), the absent or diminished dystrophin leads to progressive skeletal muscle and heart failure.
Kaklamanis Loukas, Polymeros Spyridon, Demerouti Eftichia, Kolovou Genovefa, Georgakopoulos Dimitris, Karanasios Evangelos, Papadopoulos George, Constandoulakis Pantelis, Spargias Kostas, Papavasiliou Antigoni, Mavrogeni Sophie, Magoutas Anastasios, Papadopoulou Evangelia, Markussis Vyron, Cokkinos Dennis V   +14 more
doaj   +1 more source

The Role of Sarcopenia in Heart Failure with Depression

Reviews in Cardiovascular Medicine, 2022
Heart failure (HF) and depression are both major medical health issues in our society. Currently, an increasing number of studies demonstrate an association between HF and depression.
Ruting Wang, Jiahao Duan, Wei Liu, Kai Huang, Zijun Chen, Chun Yang, Ling Yang   +6 more
doaj   +1 more source

Obesity Subtypes and Longitudinal Trajectories of Function Over Seven Years of Follow‐Up: Data From the Multicenter Osteoarthritis Study

Arthritis Care &Research, EarlyView.
Objective Obesity, defined by body mass index (BMI) ≥30 kg/m2, is a risk factor for functional limitations in people with knee osteoarthritis (OA). However, function varies among such individuals. Our objective was to evaluate the implications of obesity subtypes on longitudinal patterns of physical functioning in people with or at risk for knee OA ...
Kristine Godziuk, Sarah Tilley, Michael LaValley, Michael C. Nevitt, Cora E. Lewis, James C. Torner, Tuhina Neogi, for the Multicenter Osteoarthritis Study Group   +7 more
wiley   +1 more source

Stachydrine alleviates lipid-induced skeletal muscle insulin resistance via AMPK/HO-1-mediated suppression of inflammation and endoplasmic reticulum stress

, 2022
Objective Insulin resistance develops due to skeletal muscle inflammation and endoplasmic reticulum (ER) stress. Stachydrine (STA), extracted from Leonurus heterophyllus, has been shown to suppress proliferation and induce apoptosis in breast cancer ...
Lee, H. J., Jeong, J. H., Abd El-Aty, A. M., Jung, T. W., Hacimuftuoglu, Ahmet, Park, S. Y., Kim, H., Cho, W., Oh, H.   +8 more
core   +1 more source

Skeletal muscle BMAL1 is necessary for transcriptional adaptation of local and peripheral tissues in response to endurance exercise training

Molecular Metabolism
Objective: In this investigation, we addressed the contribution of the core circadian clock factor, BMAL1, in skeletal muscle to both acute transcriptional responses to exercise and transcriptional remodeling in response to exercise training ...
Mark R. Viggars, Hannah E. Berko, Stuart J. Hesketh, Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Ryan A. Martin, Isabel G. Jennings, Zhiguang Huo, Karyn A. Esser   +8 more
doaj   +1 more source

Acute and long-term effects of exposure to sodium monofluoroacetate (1080) in sheep

Onderstepoort Journal of Veterinary Research, 2008
Acute and long-term effects of a single, relative lyhigh oral dose (0.25a nd 0.30 mg/kg) of sodium monofluoroacetate (1080) on the survival and productivity of sheep were evaluated to establish a better understanding of 1080 poisoning and identify more ...
S. R. Gooneratne, C. T. Eason, L. Milne, D. G. Arthur, C. Cook, M. Wickstrom   +5 more
doaj   +1 more source

Genetic deletion of Kvβ2 (AKR6) causes loss of muscle function and increased inflammation in mice

Frontiers in Aging, 2023
The voltage-gated potassium channels (Kv) are complex ion channels with distinct roles in neurotransmission, electrical conductivity of the heart, and smooth and striated muscle functions. Previously, we demonstrated that deletion of Kvβ2 in mice results
Ravikumar Manickam, Jazmine Virzi, Anish Potti, Feng Cheng, David W. Russ, Srinivas M. Tipparaju   +5 more
doaj   +1 more source

Pull‐and‐Push Nanotherapeutic Hydrogels: Scavenging Inflammatory Triggers While Driving Tissue Regeneration in Burn Wounds

Advanced Functional Materials, EarlyView.
A nanounit‐assembled hydrogel employing a “pull‐and‐push” strategy simultaneously scavenges pro‐inflammatory cell‐free DNA (cfDNA) and delivers regenerative therapeutics in response to burn‐induced hyperthermia. By repolarizing macrophages and promoting angiogenesis, this multifunctional platform accelerates burn wound healing, offering a blueprint for
Han‐Sem Kim, Seong‐Jin Shin, Sak Lee, Nandin Mandakhbayar, Ji‐Hye Kang, Da‐Young Kong, Seong‐Doo Hong, Ueon Sang Shin, Hae‐Won Kim, Jung‐Hwan Lee   +9 more
wiley   +1 more source

The effects of inspiratory muscle training on plasma interleukin-6 concentration during cycling exercise and a volitional mimic of the exercise hyperpnea

, 2013
It is unknown whether the respiratory muscles contribute to exercise-induced increases in plasma interleukin-6 (IL-6) concentration, if this is related to diaphragm fatigue, and whether inspiratory muscle training (IMT) attenuates the plasma IL-6 ...
Gonzalez, JT, Mills, Dean E., Gonzalez, Javier T., Neil C. Williams, Sharpe, GR, Sharpe, Graham R., McPhilimey, Martin J., Williams, NC, Mills, Dean, Gonzalez, Javier, McPhilimey, Martin, McPhilimey, MJ, Johnson, Michael A., Yvonne A. Barnett, Graham R. Sharpe, Barnett, YA, Martin J. McPhilimey, Mills, DE, Barnett, Yvonne, Javier T. Gonzalez, Sharpe, Graham, Williams, Neil C., Dean E. Mills, Johnson, MA, Barnett, Yvonne A., Michael A. Johnson, Williams, Neil   +26 more
core   +1 more source