Results 81 to 90 of about 5,647,260 (394)

Ventricular arrhythmias in young competitive athletes: Prevalence, determinants, and underlying substrate [PDF]

, 2018
Whether ventricular arrhythmias (VAs) represent a feature of the adaptive changes of the athlete's heart remains elusive. We aimed to assess the prevalence, determinants, and underlying substrates of VAs in young competitive athletes.Background--Whether ...
Badano, Luigi Paolo, Bellu, Roberto, Berton, Giampaolo, Cipriani, Alberto, Corrado, Domenico, D'Ascenzi, Flavio, De Lazzari, Manuel, Iliceto, Sabino, Mastella, Giulio, Muraru, Denisa, Niero, Alice, Palermo, Chiara, Perazzolo Marra, Martina, Peruzza, Francesco, Portolan, Leonardo, Schiavon, Maurizio, Sciacca, Federco, Tollot, Saverio, Trovato, Domenico, Zorzi, Alessandro   +19 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Neonatal lupus with atypical cardiac and cutaneous manifestation [PDF]

, 2013
Neonatal lupus erythematosus is a rare, passively acquired autoimmune disease, caused by maternal autoantibodies. The most common manifestations are skin rash and congenital heart block. Cutaneous manifestations may be present at birth, but often develop
Mimoso, G, Morais, S, Pereira, DF, Santos, IC   +3 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dual Chamber Pacemaker Implant in Coronary Sinus Leading to Several Complications

Diagnostics
Permanent pacemaker implantation is a low-risk procedure. However, complications may occur at a rate of around 4–8%. We present a case where initial implantation resulted in complications that could have been avoided by meticulous assessment of lead ...
Nancy Wassef, Mina Ibrahim, Christine Botrous, Amr Anos, Kai Hogrefe, Janaka Pathiraja   +5 more
doaj   +1 more source

Bundle Branch Reentrant Ventricular Tachycardia [PDF]

, 2005
Bundle branch reentrant (BBR) tachycardia is an uncommon form of ventricular tachycardia (VT) incorporating both bundle branches into the reentry circuit.
Kusniec, Jairo, Mazur, Alexander, Strasberg, Boris   +2 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Atrial undersensing-associated premature atrial contractions: A case report [PDF]

Scripta Medica
Atrial undersensing is defined as the inability of the pacemaker to detect spontaneous atrial activity. A case of premature atrial contractions associated with atrial undersensing is presented.
Skakun Oleksiy, Vandzhura Yaroslava, Vandzhura Ihor, Symchych Khrystyna, Symchych Anton   +4 more
doaj   +1 more source

Bloqueio Aurículo-Ventricular Completo Congénito. Caso Clínico e Revisão da Literatura [PDF]

, 2015
Introduction: Congenital complete atrioventricular block (AVB) without cardiac malformation is a rare and potentially fatal condition. In most cases it is associated with maternal systemic lupus erythematosus through transplacental passage of antibodies ...
Borges, A, Freitas, I, Massa, AC, Serrano, F   +3 more
core