Results 11 to 20 of about 188,628 (354)

Recruitment of the cardiac conduction system for optimal resynchronization therapy in failing heart

Frontiers in Physiology, 2022
Heart failure (HF) is a leading health burden around the world. Although pharmacological development has dramatically advanced medication therapy in the field, hemodynamic disorders or mechanical desynchrony deteriorated by intra or interventricular ...
Zhongli Chen, Xiaohong Zhou, Xuan Ma, Keping Chen   +3 more
doaj   +1 more source

Neonatal Deletion of Hand1 and Hand2 within Murine Cardiac Conduction System Reveals a Novel Role for HAND2 in Rhythm Homeostasis

Journal of Cardiovascular Development and Disease, 2022
The cardiac conduction system, a network of specialized cells, is required for the functioning of the heart. The basic helix loop helix factors Hand1 and Hand2 are required for cardiac morphogenesis and have been implicated in cardiac conduction system ...
Rajani M. George, Shuai Guo, Beth A. Firulli, Michael Rubart, Anthony B. Firulli   +4 more
doaj   +1 more source

Purkinje Cardiomyocytes of the Adult Ventricular Conduction System Are Highly Diploid but Not Uniquely Regenerative

Journal of Cardiovascular Development and Disease, 2023
Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify.
Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov   +9 more
doaj   +1 more source

Giant cell myocarditis masquerading as orbital myositis with a rapid, fulminant course necessitating mechanical support and heart transplantation. [PDF]

, 2017
Giant cell myocarditis (GCM), a rapidly progressive inflammation of the myocardium, is associated with fulminant heart failure, refractory ventricular arrhythmias, and conduction system abnormalities.
Aksoy, Olcay, Ardehali, Reza, Garg, Vinisha, Huynh, Tracy, Shah, Janki, Tan, Weiyi   +5 more
core   +1 more source

High resolution 3-Dimensional imaging of the human cardiac conduction system from microanatomy to mathematical modeling [PDF]

, 2017
Cardiac arrhythmias and conduction disturbances are accompanied by structural remodelling of the specialised cardiomyocytes known collectively as the cardiac conduction system.
A Atkinson, B Schmitt, CM Ambrosi, CM Ambrosi, D Sánchez-Quintana, E VR de Castroviejo, F Davies, GV Chow, H Dobrzynski, H Dobrzynski, H Kurosawa, ID Greener, J Li, J Zhao, JC Hutchinson, JC Jarvis, KH Yiu, KHWJ Tusscher ten, M Loukas, M Smerup, M Smerup, MR Boyett, MR Boyett, N Chandler, N Piazza, N-Y Chan, NJ Chandler, NS Jeffery, O Aslanidi, OV Aslanidi, OV Aslanidi, PM Gignac, PW Oosthoek, RC Truex, RH Anderson, RH Anderson, RS Stephenson, RS Stephenson, S Dawkins, S Inada, S Yoo, T Nikolaidou, T-a Matsuyama, TA Csepe, TD Butters, VV Fedorov, VV Fedorov, WJ Hucker, Y Wang, Y-S Ko   +49 more
core   +1 more source

Specialized impulse conduction pathway in the alligator heart

eLife, 2018
Mammals and birds have a specialized cardiac atrioventricular conduction system enabling rapid activation of both ventricles. This system may have evolved together with high heart rates to support their endothermic state (warm-bloodedness) and is ...
Bjarke Jensen, Bastiaan J Boukens, Dane A Crossley II, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera, Igor R Efimov, Vincent M Christoffels   +11 more
doaj   +1 more source

Premature MicroRNA-1 Expression Causes Hypoplasia of the Cardiac Ventricular Conduction System. [PDF]

, 2019
Mammalian cardiac Purkinje fibers (PFs) are specified from ventricular trabecular myocardium during mid-gestation and undergo limited proliferation before assuming their final form.
Evangelista, Melissa, Galang, Giselle, Samal, Eva, Srivastava, Deepak, Vedantham, Vasanth, Zhao, Yong   +5 more
core   +2 more sources

Modeling the Heart as a Communication System [PDF]

, 2014
Electrical communication between cardiomyocytes can be perturbed during arrhythmia, but these perturbations are not captured by conventional electrocardiographic metrics.
Aguilar-Rodríguez, José, Ashikaga, Hiroshi, Garland, Joshua, Gorsky, Shai, Lusczek, Elizabeth, Marquitti, Flávia Maria Darcie, Thompson, Brian, Wu, Degang   +7 more
core   +2 more sources

Identifying the evolutionary building blocks of the cardiac conduction system.

PLoS ONE, 2012
The endothermic state of mammals and birds requires high heart rates to accommodate the high rates of oxygen consumption. These high heart rates are driven by very similar conduction systems consisting of an atrioventricular node that slows the ...
Bjarke Jensen, Bastiaan J D Boukens, Alex V Postma, Quinn D Gunst, Maurice J B van den Hoff, Antoon F M Moorman, Tobias Wang, Vincent M Christoffels   +7 more
doaj   +1 more source

Anatomic-electrophysiological correlations concerning the pathways for atrioventricular conduction. [PDF]

, 2001
The remarkable success of radiofrequency ablation in recent decades in curing atrioventricular nodal reentrant tachycardias has intensified efforts to provide a solid theoretical basis for understanding the mechanisms of atrioventricular transmission ...
Anderson, RH, Ho, SY, Mazgalev, TN
core   +1 more source