Results 21 to 30 of about 94,373 (304)

Variant Intronic Enhancer Controls SCN10A-Short Expression and Heart Conduction [PDF]

open access: yes, 2021
BACKGROUND: Genetic variants in SCN10A, encoding the neuronal voltage-gated sodium channel Na V1.8, are strongly associated with atrial fibrillation, Brugada syndrome, cardiac conduction velocities, and heart rate.
Verkerk, Arie O   +11 more
core   +1 more source

Conduction Disturbances Associated with TAVR [PDF]

open access: yes, 2023
Despite the improvement in the incidence of periprocedural complications associated with transcatheter aortic valve replacement (TAVR), conduction disturbances remain the most frequent complication of TAVR procedures.
Gomez, Camilo A   +2 more
core   +1 more source

Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders [PDF]

open access: yes, 2013
Elevated resting heart rate is associated with greater risk of cardiovascular disease and mortality. In a 2-stage meta-analysis of genome-wide association studies in up to 181,171 individuals, we identified 14 new loci associated with heart rate and ...
Kooner, A.S.   +999 more
core   +1 more source

Biphasic development of the mammalian ventricular conduction system. [PDF]

open access: yes, 2010
International audienceRATIONALE:The ventricular conduction system controls the propagation of electric activity through the heart to coordinate cardiac contraction.
N. Moreno-Rascon   +15 more
core   +1 more source

Identifying the evolutionary building blocks of the cardiac conduction system.

open access: yesPLoS ONE, 2012
The endothermic state of mammals and birds requires high heart rates to accommodate the high rates of oxygen consumption. These high heart rates are driven by very similar conduction systems consisting of an atrioventricular node that slows the ...
Bjarke Jensen   +7 more
doaj   +1 more source

Patterning and Development of the Conduction System of the Heart [PDF]

open access: yes, 2010
This chapter focuses on the cellular origin of the conduction system components and the molecular genetic mechanisms that may control their phenotype and position within the developing heart. It discusses the connection between heart cell precursor pools,
Hoogaars, Willem M. H.   +5 more
core   +1 more source

Cardiac resynchronisation therapy and myocardial metabolism: acute and chronic effects in heart failure [PDF]

open access: yes, 2022
Since its development in the 1990s, cardiac resynchronisation therapy has evolved to occupy a key position in the management of heart failure with a reduced ejection fraction and broadened QRS duration, inducing both acute haemodynamic improvements as ...
Green, Peregrine G
core   +2 more sources

Innovations and mechanisms in pacing therapy for heart failure [PDF]

open access: yes, 2022
Despite pharmacological advances, heart failure remains a major cause of mortality and morbidity. Pacing therapy for heart failure was achieved in the 1990s with the advent of biventricular pacing (BVP).
Arnold, Ahranyan
core   +1 more source

Differentiation of the Atrioventricular Conducting System of the Heart [PDF]

open access: yesCirculation, 1961
The structure and function of the atrioventricular conducting system of the heart, and its relationship to the myocardium, are examined from a developmental point of view. On the basis of information derived from electron micrographic, electrophysiologic, and developmental studies of heart tissue, it is concluded that: (1) The idea of the syncytial ...
Ludwig W. Eichna, ROBERT L. DEHAAN
openaire   +2 more sources

Histochemical study of the heart conduction system [PDF]

open access: yes, 1980
The distribution of acid phosphatase and succinic dehydrogenase in the specialized muscle fibers constructing the heart conduction system (sinoatrial node, atrioventricular node, atrioventricular bundle and Purkinje fibers) and the ordinary heart muscle ...
Tatsuhiko MUKUDAI, Mukudai, Tatsuhiko
core   +1 more source

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