Results 11 to 20 of about 94,373 (304)

Specialized impulse conduction pathway in the alligator heart [PDF]

eLife, 2018
Mammals and birds have a specialized cardiac atrioventricular conduction system enabling rapid activation of both ventricles. This system may have evolved together with high heart rates to support their endothermic state (warm-bloodedness) and is ...
Bjarke Jensen, Bastiaan J Boukens, Dane A Crossley II, Justin Conner, Rajiv A Mohan, Karel van Duijvenboden, Alex V Postma, Christopher R Gloschat, Ruth M Elsey, David Sedmera, Igor R Efimov, Vincent M Christoffels   +11 more
doaj   +2 more sources

Dbh + catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart [PDF]

Nature Communications, 2023
The heterogeneity of functional cardiomyocytes arises during heart development, which is essential to the complex and highly coordinated cardiac physiological function.
Tianyi Sun, Alexander Grassam-Rowe, Zhaoli Pu, Yangpeng Li, Huiying Ren, Yanru An, Xinyu Guo, Wei Hu, Ying Liu, Yuqing Zheng, Zhu Liu, Kun Kou, Xianhong Ou, Tangting Chen, Xuehui Fan, Yangyang Liu, Shu Tu, Yu He, Yue Ren, Ao Chen, Zhouchun Shang, Zhidao Xia, Lucile Miquerol, Nicola Smart, Henggui Zhang, Xiaoqiu Tan, Weinian Shou, Ming Lei   +27 more
doaj   +3 more sources

Complete Heart Block Lacking Functional Anatomical Impairment in the Conduction System [PDF]

Pakistan Journal of Medicine and Dentistry
Introduction: Complete heart block also known as third-degree atrioventricular block (AV block) is a condition in which there is no conduction of the impulse produce in the sinoatrial node (SA node) in the atrium to the ventricle.1 Complete heart ...
Shazia Yasir, Komal Owais, Ishratullah
doaj   +1 more source

Frontiers in conduction system pacing: treatment of long PR in patients with heart failure [PDF]

, 2023
Patients with heart failure who have a prolonged PR interval are at a greater risk of adverse clinical outcomes than those with a normal PR interval. Potential mechanisms of harm relating to prolonged PR intervals include reduced ventricular filling and ...
Keene, Daniel, Kaza, Nandita, Vijayaraman, Pugazhendhi, Whinnett, Zachary   +3 more
core   +1 more source

Anatomical considerations and emerging strategies for reducing new onset conduction disturbances in percutaneous structural heart disease interventions [PDF]

, 2021
Transcatheter procedures offer an alternative to cardiac surgery in select patients with structural heart disease (SHD). Unfortunately, inadvertent disruption of electrical pathways and subsequent development of new onset conduction disturbances can ...
Sievert, Horst, Albaghdadi, Mazen S, Kuck, Karl-Heinz, Ho, Siew Yen, Mahapatra, Srijoy, Tzikas, Apostolos, Kronzon, Itzhak, Leon, Martin B, Kadlec, Andrew O, Romanov, Alexander, Siddiqui, Usman, Young, Michael Nguyen   +11 more
core   +1 more source

Conduction system pacing in pediatric and congenital heart disease

Frontiers in Physiology, 2023
Conduction system pacing (CSP) has evolved rapidly to become the pacing method of choice for many adults with structurally normal hearts. Studies in this population have repeatedly demonstrated superior hemodynamics and outcomes compared to conventional ...
Henry Chubb, Douglas Mah, Anne M. Dubin, Jeremy Moore, Jeremy Moore, Jeremy Moore   +5 more
doaj   +1 more source

Recruitment of the cardiac conduction system for optimal resynchronization therapy in failing heart

Frontiers in Physiology, 2022
Heart failure (HF) is a leading health burden around the world. Although pharmacological development has dramatically advanced medication therapy in the field, hemodynamic disorders or mechanical desynchrony deteriorated by intra or interventricular ...
Zhongli Chen, Xiaohong Zhou, Xuan Ma, Keping Chen   +3 more
doaj   +1 more source

Purkinje Cardiomyocytes of the Adult Ventricular Conduction System Are Highly Diploid but Not Uniquely Regenerative

Journal of Cardiovascular Development and Disease, 2023
Adult hearts are characterized by inefficient regeneration after injury, thus, the features that support or prevent cardiomyocyte (CM) proliferation are important to clarify.
Hirofumi Watanabe, Ge Tao, Peiheng Gan, Baylee C. Westbury, Kristie D. Cox, Kelsey Tjen, Ruolan Song, Glenn I. Fishman, Takako Makita, Henry M. Sucov   +9 more
doaj   +1 more source

Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression [PDF]

, 2020
The components of the cardiac conduction system, responsible for coordinated activation of the heart chambers, are well defined and their cells differ in gene expression profile and phenotype from those of the surrounding working myocardium.
Christoffels, Vincent M., Stefanovic, Sonia, van Eif, Vincent W. W., Mohan, Rajiv A.   +3 more
core   +3 more sources

Neonatal Deletion of Hand1 and Hand2 within Murine Cardiac Conduction System Reveals a Novel Role for HAND2 in Rhythm Homeostasis

Journal of Cardiovascular Development and Disease, 2022
The cardiac conduction system, a network of specialized cells, is required for the functioning of the heart. The basic helix loop helix factors Hand1 and Hand2 are required for cardiac morphogenesis and have been implicated in cardiac conduction system ...
Rajani M. George, Shuai Guo, Beth A. Firulli, Michael Rubart, Anthony B. Firulli   +4 more
doaj   +1 more source