Results 51 to 60 of about 94,373 (304)

Health Literacy, Self‐Efficacy and Knowledge of Sickle Cell Disease Among Caregivers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a hereditary blood disorder in which abnormal haemoglobin leads to severe anaemia, painful crises and organ failure. Caregivers’ health literacy (HL) – their ability to assess, understand and apply information, and interact with healthcare professionals – is crucial for managing children with SCD, yet ...
Melanie Bruinooge, Maite E. Houwing, Rowena L. Grohssteiner, Ferdows Atiq, Sonja A. M. C. Teuben, Mirjam P. Fransen, Marjon H. Cnossen   +6 more
wiley   +1 more source

Electrophysiology of the Intact Neonatal Canine Atrioventricular Conducting System [PDF]

Over the past few years, there have been several clinical investigations concerning the electrophysiology of the cardiac conducting system in the neonate and pediatric patient (1,57,89,213,450,660–662).
Gelband, Henry, Bassett, Arthur L, Nilsson, Kristina, Sung, Ruey J, Myerburg, Robert J   +4 more
core   +1 more source

Connexin diversity in the heart: insights from transgenic mouse models

Frontiers in Pharmacology, 2013
Cardiac conduction is mediated by gap junction channels that are formed by connexin (Cx) protein subunits. The connexin family of proteins consists of 24 members, varying in their biophysical properties and ability to combine with other connexins into ...
Sander eVerheule, Sven eKaese
doaj   +1 more source

BMT4me En Español: Multisite Feasibility and Usability Testing of a Spanish‐Language mHealth Adherence Support App for Spanish‐Speaking Caregivers of Children After Hematopoietic Stem Cell Transplantation and Cancer Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Medication nonadherence during the first 100 days after pediatric hematopoietic stem cell transplantation (HSCT) and during oncology treatment increases risk for complications. BMT4me is a caregiver‐facing mobile health (mHealth) application providing medication reminders, symptom tracking, and note‐taking features to support ...
Micah A. Skeens, Madeline R. Peek, Bianca Franklin, Emre Sezgin, Melissa Beauchemin   +4 more
wiley   +1 more source

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function [PDF]

, 2019
RATIONALE: The ventricular conduction system (VCS) rapidly propagates electrical impulses through the working myocardium of the ventricles to coordinate chamber contraction. GWAS (Genome-wide association studies) have associated nucleotide polymorphisms,
Toolan, Kevin P., de Gier-de Vries, Corrie, Vincentz, Joshua W., Chen, Peng-Sheng, Christoffels, Vincent M., Sotoodehnia, Nona, Rubart-von der Lohe, Michael, Firulli, Beth A., Firulli, Anthony B., Arking, Dan E., Wan, Juyi   +10 more
core   +1 more source

Poster abstract: Heart base irradiation causes functional changes in the conduction system: a pre-clinical model [PDF]

, 2021
Purpose or Objective Radiation cardiotoxicity affects one third of patients with intrathoracic cancer and is largely characterised by vascular, electrical and pump dysfunction in the months-years following radical doses.
Walls, G.; id_orcid, Lisgo, S., Jain, S., Butterworth, K. ; id_orcid, Gill, E., Williams, K., McWilliam, A., Ghita, Mihaela, Queen, R., Cole, Aidan; id_orcid, van Herk, M., Grieve, D., Edgar, K.; id_orcid, Overman, L.   +13 more
core   +1 more source

Immunoglobulin Depletion and Recovery Following Blinatumomab in Infants With KMT2A‐Rearranged ALL

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Adding blinatumomab to standard chemotherapy for infants with KMT2A‐rearranged acute B‐cell lymphoblastic leukemia (KMT2A‐r B‐ALL) improves outcomes. Although blinatumomab impairs immunoglobulin G (lgG) production, increasing infection susceptibility, IgG recovery remains poorly understood.
Miguel Vieira Martins, Paola de Lorenzo, Rishi S. Kotecha, Andishe Attarbaschi, Gabriele Escherich, Karsten Nysom, Jan Stary, Alina Ferster, Benoit Brethon, Franco Locatelli, Martin Schrappe, Peggy E. Scholte‐van Houtem, Maria G. Valsecchi, Rob Pieters, Inge M. van der Sluis   +14 more
wiley   +1 more source

Development of an automated updated selvester QRS scoring system using SWT-based QRS fractionation detection and classification [PDF]

, 2014
The Selvester score is an effective means for estimating the extent of myocardial scar in a patient from lowcost ECG recordings. Automation of such a system is deemed to help implementing low-cost high-volume screening mechanisms of scar in the primary ...
Mazomenos, E B, Morgan, John M., Maharatna, K, Acharyya, Amit, Morgan, JM, Chen, T, Bono, Valentina, Mazomenos, EB, Curzen, Nick, Acharyya, A, Bono, V, Chen, Taihai, Rosengarten, James, Rosengarten, J A, Rosengarten, JA, Maharatna, Koushik, Mazomenos, Evangelos B., Curzen, N, Morgan, J M   +18 more
core   +1 more source

Real-Time In Vivo Imaging of Mouse Left Ventricle Reveals Fluctuating Movements of the Intercalated Discs

Nanomaterials, 2020
Myocardial contraction is initiated by action potential propagation through the conduction system of the heart. It has been thought that connexin 43 in the gap junctions (GJ) within the intercalated disc (ID) provides direct electric connectivity between
Fuyu Kobirumaki-Shimozawa, Tomohiro Nakanishi, Togo Shimozawa, Takako Terui, Kotaro Oyama, Jia Li, William E. Louch, Shin’ichi Ishiwata, Norio Fukuda   +8 more
doaj   +1 more source

On Hierarchical Composite Endpoints in Pediatric Cancer Supportive Care: Illustrative Examples From Two Multi‐Center Phase‐III Randomized Clinical Trials

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric supportive care clinical trials often involve multiple clinically important outcomes, complicating trial interpretation. Hierarchical composite endpoints (HCEs) provide a framework to integrate key outcomes according to clinical importance.
Willem H. Collier, Mark Zobeck, Adam J. Esbenshade, Christopher C. Dvorak, Lillian Sung, David Freyer, Sarah Alexander, Etan Orgel, Nicole J. Ullrich, Zach Prudowsky, Brian Fisher, Caitlin W. Elgarten   +11 more
wiley   +1 more source