Results 51 to 60 of about 187,698 (309)

Cardiac Arrhythmias In Congenital Heart Diseases

Indian Pacing and Electrophysiology Journal, 2009
Arrhythmias figure prominently among the complications encountered in the varied and diverse population of patients with congenital heart disease, and are the leading cause of morbidity and mortality. The incidence generally increases as the patient ages,
Paul Khairy, Seshadri Balaji
doaj  

Predictive factors of atrioventricular conduction disorders [PDF]

Romanian Medical Journal
Atrioventricular conduction disorders represent an alteration in the normal function of the heart’s electrical conduction system, a system that connects the atria and ventricles through the atrio-ventricular node and the His-Purkinje system. Consequently,
Carmen Marina Deutsch, Elisabeta Badila, Adriana Iliesiu   +2 more
doaj   +1 more source

Complex patterns of spontaneous initiations and terminations of reentrant circulation in a loop of cardiac tissue

, 2008
A two-component model is developed that consists of a discrete loop of cardiac cells that circulates action potentials together with a cardiac pacing mechanism.
Anastasiou-Nana, Banville, Bub, C.K. Cheng, C.M. Baumgarten, Cain, Cain, Cain, Cao, Chay, Chen, Cheng, Cherry, Chialvo, Chow, Courtemanche, Courtemanche, Courtemanche, Cytrynbaum, D.M. Chan, De Bakker, Derksen, Downar, Elaydi, Fox, Fox, Frame, Gilmour, Girouard, Glass, H. Sedaghat, Hall, Harris, Hwang, Ito, J.W. Cain, Jack, Jalife, Kalb, Keener, Kocic, Koller, Koller, Krebs, Kunysz, Lampert, Liebovitch, Lown, M.A. Wood, Manios, Mickens, Mines, Mitchell, Moe, Nagai, Nolasco, Otani, Plonsey, Qu, Quan, Sedaghat, Sedaghat, Stein, Stubna, Ten Tusscher, Vinet, Watanabe, Watanabe, Winkle, Wood, Wood, Wood   +71 more
core   +1 more source

Spiral-wave dynamics in a mathematical model of human ventricular tissue with myocytes and Purkinje fibers [PDF]

, 2017
We present systematic numerical studies of the possible effects of the coupling of human endocardial and Purkinje cells at cellular and two-dimensional tissue levels.
Nayak, Alok Ranjan, Pandit, Rahul, Panfilov, Alexander   +2 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms. [PDF]

, 2015
Cardiac dysfunction is a prominent cause of mortality in myotonic dystrophy I (DM1), a disease where expanded CUG repeats bind and disable the muscleblind-like family of splice regulators.
Choi, Jongkyu, Comai, Lucio, Dixon, Donald M, El-Ghazali, Ayea, Fishbein, Michael C, Jordan, Maria C, Park, Sun Young, Reddy, Sita, Roos, Kenneth P   +8 more
core  

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12 [PDF]

, 2019
Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 ...
Ai, Tomohiko, Chang, Po-Cheng, Chen, Hanying, Chen, Peng-Sheng, Fishbein, Michael C., Homsi, Mohamed, Li, Bai-Yan, Lin, Shien-Fong, Liu, Jijia, Liu, Ying, Maruyama, Mitsunori, Pan, Zhenwei, Rubart, Michael, Shou, Weinian, Xiao, Deyong   +14 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Conduction System Pacing in Children and Congenital Heart Disease

Arrhythmia & Electrophysiology Review
Permanent cardiac pacing in children with congenital complete atrioventricular block (CCAVB) and/or congenital heart disease (CHD) is challenging.
Óscar Cano, Jeremy P Moore
doaj   +1 more source

Development of the Cardiac Conduction System and the Possible Relation to Predilection Sites of Arrhythmogenesis

The Scientific World Journal, 2008
The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties ...
M. R. M. Jongbloed, E. A. F. Mahtab, N. A. Blom, M. J. Schalij, A. C. Gittenberger-de Groot   +4 more
doaj   +1 more source