Results 51 to 60 of about 93,944 (304)

Connexin diversity in the heart: insights from transgenic mouse models

Frontiers in Pharmacology, 2013
Cardiac conduction is mediated by gap junction channels that are formed by connexin (Cx) protein subunits. The connexin family of proteins consists of 24 members, varying in their biophysical properties and ability to combine with other connexins into ...
Sander eVerheule, Sven eKaese
doaj   +1 more source

Cardiac resynchronisation therapy and myocardial metabolism: acute and chronic effects in heart failure

, 2022
Since its development in the 1990s, cardiac resynchronisation therapy has evolved to occupy a key position in the management of heart failure with a reduced ejection fraction and broadened QRS duration, inducing both acute haemodynamic improvements as ...
Green, Peregrine G
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Development of an automated updated selvester QRS scoring system using SWT-based QRS fractionation detection and classification [PDF]

, 2014
The Selvester score is an effective means for estimating the extent of myocardial scar in a patient from lowcost ECG recordings. Automation of such a system is deemed to help implementing low-cost high-volume screening mechanisms of scar in the primary ...
Mazomenos, E B, Morgan, John M., Maharatna, K, Acharyya, Amit, Morgan, JM, Chen, T, Bono, Valentina, Mazomenos, EB, Curzen, Nick, Acharyya, A, Bono, V, Chen, Taihai, Rosengarten, James, Rosengarten, J A, Rosengarten, JA, Maharatna, Koushik, Mazomenos, Evangelos B., Curzen, N, Morgan, J M   +18 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Cardiac Arrhythmias In Congenital Heart Diseases

Indian Pacing and Electrophysiology Journal, 2009
Arrhythmias figure prominently among the complications encountered in the varied and diverse population of patients with congenital heart disease, and are the leading cause of morbidity and mortality. The incidence generally increases as the patient ages,
Paul Khairy, Seshadri Balaji
doaj  

Predictive factors of atrioventricular conduction disorders [PDF]

Romanian Medical Journal
Atrioventricular conduction disorders represent an alteration in the normal function of the heart’s electrical conduction system, a system that connects the atria and ventricles through the atrio-ventricular node and the His-Purkinje system. Consequently,
Carmen Marina Deutsch, Elisabeta Badila, Adriana Iliesiu   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Development of the Cardiac Conduction System and the Possible Relation to Predilection Sites of Arrhythmogenesis

The Scientific World Journal, 2008
The cardiac conduction system (CCS) encompasses a complex system responsible for the coordinated contraction of the heart. In the developing heart, as well as in the adult heart, tissues of the (putative) CCS are characterized by different properties ...
M. R. M. Jongbloed, E. A. F. Mahtab, N. A. Blom, M. J. Schalij, A. C. Gittenberger-de Groot   +4 more
doaj   +1 more source