Results 61 to 70 of about 187,698 (309)

Revolutionizing cardiovascular medicine: targeted therapies for the cardiac conduction system

The Journal of Clinical Investigation, 2022
Arrhythmogenic cardiovascular disorders are associated with considerable morbidity and mortality. Whether cardiac conduction disease is caused by genetic defects, procedural perturbations, valvular disease, ischemia, aging, or heart failure, new ...
Daniel J. Garry, Demetris Yannopoulos, Tamas Alexy   +2 more
doaj   +1 more source

A concise review on the anatomy of the atrioventricular node in mammals [PDF]

The Iranian Journal of Veterinary Science and Technology, 2009
Cardiac conduction system enables the heart to pulsate continuously by producing electric impulse and conducting it. As the anatomical information about cardiac conduction system in human being and other mammals needed in various fields of sciences, such
Abolghassem Nabipour
doaj   +1 more source

Termination of Reentry in an Inhomogeneous Ring of Model Cardiac Cells [PDF]

, 2002
Reentrant waves propagating in a ring or annulus of excitable media model is the basic mechanism underlying a major class of irregular cardiac rhythms known as anatomical reentry.
Christini, David J., Sinha, Sitabhra
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Prevalence of cardiac fibrosis and infiltrative cardiomyopathy in patients with advanced conduction system disease

Journal of Arrhythmia
Background Conduction system disease may represent an early manifestation of underlying structural heart disease, including infiltrative disorders.
Jeremy William, Haider Muthana, Joseph Hogarty, Andrew Taylor, James L. Hare, Justin Mariani, Hitesh Patel, Geoff Wong, Dion Stub, David M. Kaye, Sandeep Prabhu, Peter M. Kistler, Aleksandr Voskoboinik   +12 more
doaj   +1 more source

Complete atrioventricular block during renal transplantation in a patient with Alport's syndrome: case report

São Paulo Medical Journal, 2001
CONTEXT: Patients with Alport's syndrome (causing 5% of end-stage renal disease) have a higher risk of heart conduction abnormalities. OBJECTIVE: To report a case of Alport's syndrome developing complete atrioventricular block during renal ...
Fábio Ferrari, Paulo do Nascimento Junior, Pedro Thadeu Galvão Vianna   +2 more
doaj   +1 more source

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Adeniran, I., Amuzu, A., Braund, P.S., Burton, P.R., Casas, J.-P., Day, I.N.M., Drenos, F., Eriksson, P., Folkersen, L., Gaunt, T.R., Hancox, J.C., Hingorani, A.D., Humphries, S.E., Kivimaki, M., Kumari, M., Lawlor, D.A., Macfarlane, P.W., Nelson, C.P., Samani, N.J., Shah, S., Talmud, P.J., Tobin, M.D., Tomaszewski, M., Whittaker, J., Zhang, H.   +24 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Evolution of the Sinus Venosus from Fish to Human

Journal of Cardiovascular Development and Disease, 2014
The sinus venosus, the cardiac chamber upstream of the (right) atrium, is a severely underinvestigated structure. Yet, its myocardium harbors the cardiac pacemaker in all vertebrates.
Bjarke Jensen, Bastiaan J. D. Boukens, Tobias Wang, Antoon F. M. Moorman, Vincent M. Christoffels   +4 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source