Results 81 to 90 of about 94,373 (304)

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart [PDF]

, 2004
OBJECTIVE: The molecular mechanisms that regulate the formation of the conduction system are poorly understood. We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine ...
Hoogaars, Willem M. H., Soufan, Alexandre T., Hagoort, Jaco, Campione, Marina, Christoffels, Vincent M., Tessari, Alessandra, Moorman, Antoon F. M., de Boer, Piet A. J.   +7 more
core   +1 more source

Comparing the effects of three local anaesthetic agents on cardiac conduction system - A randomised study

Indian Journal of Anaesthesia
Background and Aims: This study aimed to compare the effects of three local anaesthetic (LA) agents, namely bupivacaine, levobupivacaine, and ropivacaine, on the cardiac conduction system as assessed by corrected QT (QTc) and P wave dispersion (PWD ...
Vaishali Agarwal, Pravin K. Das, Soumya S. Nath, Manoj Tripathi, Bhuwan Tiwari   +4 more
doaj   +1 more source

Restoring heart function and electrical integrity: closing the circuit

npj Regenerative Medicine, 2017
Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity.
Luís Miguel Monteiro, Francisco Vasques-Nóvoa, Lino Ferreira, Perpétua Pinto-do-Ó, Diana Santos Nascimento   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Evaluation of the human heart conduction system visualization possibilities based on morphospectral and proteomic investigations. [PDF]

, 2010
The theme covered in the dissertation is about investigation of the morphological differences of the conduction system of the human heart and those of other heart tissues, applying spectroscopic, histochemical and proteomic methods.
Žurauskas, Edvardas,
core  

Conduction defects and arrhythmias in mdx mice are not associated with a degeneration of the cardiac Purkinje network

Frontiers in Physiology
Duchenne muscular dystrophy (DMD) is a severe X-chromosomal disease characterised by progressive muscle weakness and degeneration. Cardiac involvement is inevitable in DMD patients and ventricular arrhythmias are a high-risk factor for mortality in these
Juliette Vahdat, Jakob Sauer, Jessica Marksteiner, Karlheinz Hilber, Lucile Miquerol   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transcriptional regulation of the cardiac conduction system [PDF]

, 2018
The rate and rhythm of heart muscle contractions are coordinated by the cardiac conduction system (CCS), a generic term for a collection of different specialized muscular tissues within the heart. The CCS components initiate the electrical impulse at the
Christoffels, Vincent M., Gerard J. J. Boink, Vincent W. W. van Eif, Harsha D. Devalla, Boink, Gerard J. J., Vincent M. Christoffels, van Eif, Vincent W. W., Devalla, Harsha D.   +7 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source