Results 101 to 110 of about 20,033,761 (330)

Integration of genetics into a systems model of electrocardiographic traits using humanCVD BeadChip [PDF]

, 2012
<p>Background—Electrocardiographic traits are important, substantially heritable determinants of risk of arrhythmias and sudden cardiac death.</p> <p>Methods and Results—In this study, 3 population-based cohorts (n=10 526) genotyped ...
Nelson, C.P., Whittaker, John, Kumari, Meena, Folkersen, Lasse, Lasse Folkersen, Drenos, F., Drenos, Fotios, Kumari, M., Nelson, Christopher P, Amuzu, A., Mika Kivimaki, Nilesh J. Samani, Braund, P.S., Folkersen, L., Whittaker, J., Juan-Pablo Casas, John Whittaker, Eriksson, Per, Burton, P.R., Christopher P. Nelson, Meena Kumari, Zhang, H., Tom R. Gaunt, Debbie A. Lawlor, Casas, J.-P., Peter S. Braund, Adeniran, Ismail, Samani, Nilesh J, Sonia Shah, Samani, N.J., Antoinette Amuzu, Amuzu, Antoinette, Humphries, S.E., Zhang, Henggui, Henggui Zhang, Philippa J. Talmud, Day, I.N.M., Hancox, Jules C, Hancox, J.C., Tomaszewski, M., Hingorani, Aroon D, Burton, Paul R, Maciej Tomaszewski, Lawlor, D.A., Jules C. Hancox, Ian N.M. Day, Steve E. Humphries, Kivimaki, Mika, Kivimaki, M., Tobin, Martin D, Lawlor, Debbie A, Hingorani, A.D., Per Eriksson, Eriksson, P., Tomaszewski, Maciej, Peter W. Macfarlane, Humphries, Steve E, Shah, S., Ismail Adeniran, Day, Ian NM, Macfarlane, P.W., Martin D. Tobin, Paul R. Burton, Day, Ian N M, Gaunt, Tom R, Macfarlane, Peter W, Adeniran, I., Fotios Drenos, Shah, Sonia, Talmud, Philippa J, Gaunt, T.R., Tobin, M.D., Casas, Juan-Pablo, Talmud, P.J., Braund, Peter S, Tomaszewski, Maciej; id_orcid, Aroon D. Hingorani, Nelson, CP, Tobin, M., Hancox, Jules C., Casas, J-P, Shah, S, Casas, J., Drenos, F, Folkersen, L, Samani, Nilesh J., Burton, Paul R., Nelson, C., Hancox, J., Talmud, Philippa J., Macfarlane, Peter W., Gaunt, TR, Braund, P., Lawlor, D., Lawlor, DA, Gaunt, T., Burton, P., et al., Braund, Peter S., Day, Ian N.M., Adeniran, I, Tobin, Martin D., Humphries, S., Talmud, P., Lawlor, Debbie A., Amuzu, A, Braund, PS, Hingorani, Aroon D., Humphries, Steve E.   +108 more
core   +1 more source

An anatomy-guided whole-heart framework for computational modelling of the complete human cardiac conduction system

Frontiers in Cardiovascular Medicine
IntroductionComputational models of cardiac electrophysiology are increasingly used to investigate arrhythmia mechanisms and evaluate therapeutic interventions, yet most existing frameworks omit or oversimplify the cardiac conduction system, limiting ...
Mohammadreza Kariman, Christoph M. Augustin, Christoph M. Augustin, Thomas Schrotter, Matthias A. F. Gsell, Edward J. Vigmond, Gernot Plank, Gernot Plank   +7 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Conduction defects and arrhythmias in mdx mice are not associated with a degeneration of the cardiac Purkinje network

Frontiers in Physiology
Duchenne muscular dystrophy (DMD) is a severe X-chromosomal disease characterised by progressive muscle weakness and degeneration. Cardiac involvement is inevitable in DMD patients and ventricular arrhythmias are a high-risk factor for mortality in these
Juliette Vahdat, Jakob Sauer, Jessica Marksteiner, Karlheinz Hilber, Lucile Miquerol   +4 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

The cardiac conduction system: generation and conduction of the cardiac impulse [PDF]

, 2016
The normal cardiac-conduction-system is responsible for the contraction of the heart muscle. Damage or irregular function of the cardiac conduction system can lead to serious and, in some cases, fatal clinical events.
Finlay, Dewar, Guldenring, Daniel, Bond, Raymond R., Bond, Raymond, Kennedy, Alan, McLaughlin, James, Moran, Kieran, Finlay, Dewar D., McLaughlin, James; id_orcid   +8 more
core   +2 more sources

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Evaluation of the human heart conduction system visualization possibilities based on morphospectral and proteomic investigations. [PDF]

, 2010
The theme covered in the dissertation is about investigation of the morphological differences of the conduction system of the human heart and those of other heart tissues, applying spectroscopic, histochemical and proteomic methods.
Žurauskas, Edvardas,
core  

Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation

Journal of Cardiovascular Development and Disease, 2016
The cardiac conduction system (CCS) transmits electrical activity from the atria to the ventricles to coordinate heartbeats. Atrioventricular conduction diseases are often associated with defects in the central ventricular conduction system comprising ...
Caroline Choquet, Laetitia Marcadet, Sabrina Beyer, Robert G. Kelly, Lucile Miquerol   +4 more
doaj   +1 more source