Results 91 to 100 of about 94,373 (304)

Role of Tbx3 in conduction system development [PDF]

, 2012
This thesis explores the role of transcription factor Tbx3 in the developing and mature cardiac conduction system. In the adult heart, the conduction system is responsible for the initiation and coordination of the rhythmic contraction of the heart.
Bakker, M.L., Bakker, Martijn L.
core  

Electrical Conduction System Remodeling in Streptozotocin-Induced Diabetes Mellitus Rat Heart

Frontiers in Physiology, 2019
Cardiovascular complications are common in type 1 diabetes mellitus (TIDM) and there is an increased risk of arrhythmias as a result of dysfunction of the cardiac conduction system (CCS). We have previously shown that, in vivo, there is a decrease in the
Yu Zhang, Yu Zhang, Yanwen Wang, Joseph Yanni, Mohammed Anwar Qureshi, Sunil Jit R. J. Logantha, Sarah Kassab, Mark R. Boyett, Natalie J. Gardiner, Hong Sun, Frank Christopher Howarth, Halina Dobrzynski   +11 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Regeneration of the cardiac conduction system [PDF]

Arrhythmias are a hallmark of myocardial infarction (MI) and increase mortality risk for patients. The cardiac conduction system is increasingly implicated in arrhythmias but how it is altered following MI is not well understood.
Sayers, Judy
core   +2 more sources

Segregation of Central Ventricular Conduction System Lineages in Early SMA+ Cardiomyocytes Occurs Prior to Heart Tube Formation

Journal of Cardiovascular Development and Disease, 2016
The cardiac conduction system (CCS) transmits electrical activity from the atria to the ventricles to coordinate heartbeats. Atrioventricular conduction diseases are often associated with defects in the central ventricular conduction system comprising ...
Caroline Choquet, Laetitia Marcadet, Sabrina Beyer, Robert G. Kelly, Lucile Miquerol   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Signal averaging transesophageal left heart ECG software to evaluate left atrial conduction delay and left ventricular conduction delay in heart failure patients with dilated and ischaemic cardiomyopathy [PDF]

, 2012
Cardiac resynchronization therapy with biventricular pacing is an established therapy for heart failure patients with electrical left ventricular desynchronization.
Ismer, Bruno, Lorenz, Martin, Straube, Kerstin, Figulla, Hans Reiner, Heinke, Matthias (Prof. Dr.-Ing. med. habil.)   +4 more
core   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates

Life Science Alliance
PRDM16 loss in cardiomyocytes during development causes an atrial and conduction fate shift and distal ventricular conduction system hyperplasia resulting in premature death or cardiac dysfunction.
Jore Van Wauwe, Alexia Mahy, Sander Craps, Samaneh Ekhteraei-Tousi, Pieter Vrancaert, Hannelore Kemps, Wouter Dheedene, Rosa Doñate Puertas, Sander Trenson, H. Llewelyn Roderick, Manu Beerens, Aernout Luttun   +11 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source