Results 91 to 100 of about 20,033,761 (330)
Revolutionizing cardiovascular medicine: targeted therapies for the cardiac conduction system
The Journal of Clinical Investigation, 2022 Arrhythmogenic cardiovascular disorders are associated with considerable morbidity and mortality. Whether cardiac conduction disease is caused by genetic defects, procedural perturbations, valvular disease, ischemia, aging, or heart failure, new ...
Daniel J. Garry +2 more
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Electrophysiology of the Intact Neonatal Canine Atrioventricular Conducting System
, 1978 Over the past few years, there have been several clinical investigations concerning the electrophysiology of the cardiac conducting system in the neonate and pediatric patient (1,57,89,213,450,660–662).
Gelband, Henry +9 more
core +1 more source
Erbb2 is required for cardiac atrial electrical activity during development.
PLoS ONE, 2014 The heart is the first organ required to function during embryonic development and is absolutely necessary for embryo survival. Cardiac activity is dependent on both the sinoatrial node (SAN), which is the pacemaker of heart's electrical activity, and ...
Gennadiy Tenin +7 more
doaj +1 more source
Archives of histology and cytology, 1993 Morphological aspects of the heart conduction system have been studied by various histochemical markers. However, the actual presence of markers in the conduction system and its developmental mode remain controversial.
N. Aoyama, R. Kikawada, Shohei Yamashina
semanticscholar +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Conduction system pacing (CSP) is a physiological approach to cardiac resynchronization (CRT) where cardiac electrical activation can be restored to normal.
Ali, Nadine
core +1 more source
Restoring heart function and electrical integrity: closing the circuit
npj Regenerative Medicine, 2017 Cardiovascular diseases are the main cause of death in the world and are often associated with the occurrence of arrhythmias due to disruption of myocardial electrical integrity.
Luís Miguel Monteiro +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Anatomic-electrophysiological correlations concerning the pathways for atrioventricular conduction. [PDF]
, 2001 The remarkable success of radiofrequency ablation in recent decades in curing atrioventricular nodal reentrant tachycardias has intensified efforts to provide a solid theoretical basis for understanding the mechanisms of atrioventricular transmission ...
Mazgalev, TN, Anderson, RH, Ho, SY
core