Results 71 to 80 of about 5,469,873 (362)

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications

Cardiovascular Diabetology
Background Although previous studies have evaluated renal function decline in patients with heart failure (HF), there is limited evidence on long-term renal trajectories, especially in patients with concomitant HF and type 2 diabetes (T2D).
Maria Teresa Julián, Pau Codina, Josep Lupón, Elisabet Zamora, Alejandra Pérez-Montes de Oca, Mar Domingo, Evelyn Santiago-Vacas, Andrea Borrellas, María Ruiz-Cueto, Carlos González-Gallego, Maribel Troya, Gregorio A. Romero-González, Nuria Alonso, Antoni Bayes-Genis   +13 more
doaj   +1 more source

Insuficiencia cardíaca descompensada en un solo centro de un país latinoamericano: hallazgos de los primeros 1595 casos en el registro ICARUS

Archivos de Cardiología de México
Objetivo: Describir los aspectos metodológicos, las características sociodemográficas y clínicas de los pacientes hospitalizados con ICAD y sus desenlaces a corto plazo.
Lyda Z. Rojas, Sergio A. Gómez-Ochoa, Jaime A. Rodríguez, Karen A. García-Rueda, Angela M. Torres-Bustamante, Daniel R. Botero, María Cantillo-Reines, Angie Y. Serrano-García, Adriana M. Jurado, Kelly J. Castro, Katerine Pinilla, Angie C. Mendoza-Quiñonez, Nelly J. Vasquez, Yeinmy Y. Alvarez, Maribel Rojas, Diana M. Ortega-Solano, Yesenia Sanabria, Angelica Vargas-Sanabria, Aura M. Cáceres, Paula S. Bohorquez-Hernández, Carlos Portillo, Luis E. Echeverria   +21 more
doaj   +1 more source

Machine learning can predict survival of patients with heart failure from serum creatinine and ejection fraction alone

BMC Medical Informatics and Decision Making, 2020
Background Cardiovascular diseases kill approximately 17 million people globally every year, and they mainly exhibit as myocardial infarctions and heart failures.
D. Chicco, Giuseppe Jurman
semanticscholar   +1 more source

Heart failure – or a failure of imagination? [PDF]

Postgraduate Medical Journal, 2017
Over ten years ago, Richard Lehman wrote an editorial in the BMJ proposing that we should abandon the term heart failure.1 Instead, he suggested, ‘it might be kinder, and more accurate, to start calling it cardiac impairment.’ As Lehman argued, the term heart failure covers a confusingly wide spectrum of illness ranging from asymptomatic systolic ...
openaire   +2 more sources

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction

ESC Heart Failure, 2021
Aims There is an emerging interest in elucidating the natural history and prognosis for patients with heart failure with reduced ejection fraction (HFrEF) in whom left ventricular ejection fraction (LVEF) subsequently improves.
Xinxin Zhang, Yuxi Sun, Yanli Zhang, Feifei Chen, Mengyuan Dai, Jinping Si, Jing Yang, Xiao Li, Jiaxin Li, Yunlong Xia, Gary Tse, Ying Liu   +11 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Global Public Health Burden of Heart Failure.

Cardiac failure review, 2016
Heart failure (HF) is a global pandemic affecting at least 26 million people worldwide and is increasing in prevalence. HF health expenditures are considerable and will increase dramatically with an ageing population.
G. Savarese, L. Lund
semanticscholar   +1 more source