Results 71 to 80 of about 2,706,025 (352)

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Non-adherence to ivabradine and placebo and outcomes in chronic heart failure: an analysis from SHIFT [PDF]

, 2016
Aims In heart failure, non-adherence increases events; in turn, the effect of hospitalization on adherence is incompletely understood. We explored the relationship of non-adherence to outcomes, hospitalizations with non-adherence, and the influence of
Alosco, Ambardekar, Ammassari, Balkrishnan, Böhm, Böhm, Böhm, Chobanian, Claxton, Coronary Drug Project Research Group, De Geest, Ewen, Fang, Fitzgerald, Ford, Gislason, Goldberg, Granger, Havranek, Ho, Horwitz, Jong, Laufs, Masoudi, Mazzaglia, McMurray, Mosterd, Osterberg, Rasmussen, Roger, Simpson, Swedberg, Swedberg, Vrijens, Wu, Yue   +35 more
core   +1 more source

Characteristics and outcomes of heart failure with recovered left ventricular ejection fraction

ESC Heart Failure, 2021
Aims There is an emerging interest in elucidating the natural history and prognosis for patients with heart failure with reduced ejection fraction (HFrEF) in whom left ventricular ejection fraction (LVEF) subsequently improves.
Xinxin Zhang, Yuxi Sun, Yanli Zhang, Feifei Chen, Mengyuan Dai, Jinping Si, Jing Yang, Xiao Li, Jiaxin Li, Yunlong Xia, Gary Tse, Ying Liu   +11 more
doaj   +1 more source

Long-term Survival Following Heart Transplantation for Chagas Versus Non-Chagas Cardiomyopathy: A Single-center Experience in Northeastern Brazil Over 2 Decades

Transplantation Direct, 2022
Background. Data on post–heart transplant (HT) survival of patients with Chagas cardiomyopathy (CC) are scarce. We sought to evaluate post-HT survival in patients with CC as compared with other causes of heart failure across different eras of HT. Methods.
Jefferson L. Vieira, MD, MBA, PhD, Maria G. V. Sobral, RN, Francisco Y. Macedo, MD, PhD, Raquel S. Florêncio, RN, Germana P. L. Almeida, MD, Glauber G. Vasconcelos, MD, Juliana R. Fernandes, MD, Laura L. E. Marinho, MD, Daniel F. M. Trompieri, MD, Tilak K. R. Pasala, MD, Juan A. C. Mejia, MD, João D. Souza-Neto, MD, PhD   +11 more
doaj   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

Long-term trajectory of estimated glomerular filtration rate in ambulatory patients with type 2 diabetes and heart failure: clinical insights and prognostic implications

Cardiovascular Diabetology
Background Although previous studies have evaluated renal function decline in patients with heart failure (HF), there is limited evidence on long-term renal trajectories, especially in patients with concomitant HF and type 2 diabetes (T2D).
Maria Teresa Julián, Pau Codina, Josep Lupón, Elisabet Zamora, Alejandra Pérez-Montes de Oca, Mar Domingo, Evelyn Santiago-Vacas, Andrea Borrellas, María Ruiz-Cueto, Carlos González-Gallego, Maribel Troya, Gregorio A. Romero-González, Nuria Alonso, Antoni Bayes-Genis   +13 more
doaj   +1 more source

Correction to: Low triiodothyronine syndrome and selenium deficiency - undervalued players in advanced heart failure? A single center pilot study

BMC Cardiovascular Disorders, 2019
After publication of the original article [1], the authors have notified us of a typing error in spelling Dr. Kabat’s name. The original publication has been corrected.
Magdalena Fraczek-Jucha, Katarzyna Zbierska-Rubinkiewicz, Małgorzata Kabat, Krzysztof Plens, Radoslaw Rychlak, Jadwiga Nessler, Andrzej Gackowski   +6 more
doaj   +1 more source

Diuretics for heart failure [PDF]

Cochrane Database of Systematic Reviews, 2006
Chronic heart failure is a major cause of morbidity and mortality world-wide. Diuretics are regarded as the first-line treatment for patients with congestive heart failure since they provide symptomatic relief. The effects of diuretics on disease progression and survival remain unclear.To assess the harms and benefits of diuretics for chronic heart ...
Faris, Rajaa F., Flather, Marcus D., Purcell, Henry, Poole-Wilson, Philip A., Coats, Andrew J. S.   +4 more
openaire   +5 more sources

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

Heart rate and blood pressure monitoring in heart failure. [PDF]

, 2019
It has been long known that incessant tachycardia and severe hypertension can cause heart failure (HF). In recent years, it has also been recognized that more modest elevations in either heart rate (HR) or blood pressure (BP), if sustained, can be a risk
Coats, AJS, Piepoli, MF, Ponikowski, P, Rosano, GMC, Spoletini, I   +4 more
core   +1 more source