Results 91 to 100 of about 65,782,767 (266)

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Prediction models and risk scores in different types of heart failure: a review

Frontiers in Medicine
BackgroundHeart failure (HF) is a leading cause of global disease burden and mortality. Accurate prognosis assessment is critical for reducing the risk of adverse events.
Yue Wei, Siyu Liu, Yunying Mu, Xiaoyu Liang, Ziyi Chen, Yongcheng Liu, Guoju Dong, Guoju Dong   +7 more
doaj   +1 more source

Targeting heart failure with preserved ejection fraction: current status and future prospects

, 2016
Manreet Kanwar, Claire Walter, Megan Clarke, Maria Patarroyo-Aponte Department of Cardiology, Allegheny General Hospital, Pittsburgh, PA, USA Abstract: Heart failure with preserved ejection fraction (HFpEF) portrays a significant burden in terms of ...
Walter C, Kanwar M, Patarroyo-Aponte M, Clarke M   +3 more
core  

Medical Therapies for Heart Failure With Preserved Ejection Fraction

, 2020
Current cardiovascular pharmacotherapy targets maladaptive overactivation of the renin-angiotensin-aldosterone system (RAAS), which occurs throughout the continuum of cardiovascular disease spanning from hypertension to heart failure with reduced ...
Smiseth, Otto A., Zannad, F, Mistry, Nisha, Westheim, Arne, von Lueder, Thomas Gero, Hopper, Ingrid, Wachtell, Kristian, Devereux, R. B., Reid, Christopher M., Julius, Stevo, Pitt, Bertram, Kjeldsen, Sverre   +11 more
core   +1 more source

Plasma N-Terminal Pro-Brain Natriuretic Peptide as Prognostic Marker in Fatal Cardial Decompensation with Sunitinib Malate Therapy [PDF]

, 2010
A 74-year-old man with metastatic renal cell carcinoma and a history of cardiac failure was treated with sunitinib malate. MUGA echocardiography could not detect a relevant change in the ejection fraction although the clinical situation of the patient ...
Stief, Christian G., Stadler, Thomas, Zilinberg, Katja, Haseke, Nicolas, Staehler, Michael   +4 more
core   +1 more source

Adaptive Conductive Systems: Enabling Deformable Electronics Through Engineered Materials, Circuits, and Intelligent Systems

Advanced Science, EarlyView.
This review presents the research advances of adaptive conductive systems from the perspective of materials, circuits, systems, and applications. Deformable conductors consist of substrates/matrices and conductive materials, structural design of circuit interconnections, fabrication of circuit interconnections, as well as intelligent systems ...
Yufei Lu, Siyu Liang, Jingyi Niu, Jie Chen, Shuo Zhang, Hongjian Zhang, Dongsheng Jia, Wei Huang   +7 more
wiley   +1 more source

Fibrosis-4 index can predict improved renal function in acute heart failure with preserved ejection fraction

Background Improved renal function (IRF) observed in acute heart failure (AHF) is associated with poor prognosis. Since IRF is linked to renal congestion resulting from inadequate decongestion, predicting IRF could enhance management strategies.
デヤマ, ジュンタロウ, 佐藤, 明, 市川, 優真, 吉崎, 徹, Yoshizaki, Tohru, 24896, 90535551, クロキ, ケンジ, 中村, 貴光, 30456488, ヨコミチ, ヒロシ, 出山, 順太郎, Nakamura, Kazuto, ウエマツ, マナブ, 小林, 剛, 渡邉, 陽介, 00770174, 90746629, サトウ, アキラ, 植松, 学, 23375, 24621, 30528469, Ichikawa, Yuma, 40402052, 中村, 和人, 00622151, Horikoshi, Takeo, ホリコシ, タケオ, ナカムラ, カズト, Irie, Koken, コバヤシ, ツヨシ, Sato, Akira, Uematsu, Manabu, ヨシザキ, トオル, Yokomichi, Hiroshi, 50726940, 23542, Kuroki, Kenji, 23545, 24118, 黒木, 健志, 60377512, Watanabe, Yosuke, 20596879, 25120, 25122, 24594, ワタナベ, ヨウスケ, Nakamura, Takamitsu, 横道, 洋司, ナカムラ, タカミツ, イチカワ, ユウマ, Deyama, Juntarou, 24603, Kobayashi, Tsuyoshi, 23998, 堀越, 健生, 19418   +58 more
core   +1 more source

Obesity, Preserved Ejection Fraction Heart Failure, and Left Ventricular Remodeling

, 2023
Owing to the overwhelming obesity epidemic, preserved ejection fraction heart failure commonly ensues in patients with severe obesity and the obese phenotype of preserved ejection fraction heart failure is now commonplace in clinical practice.
Jason Stencel, Daniela Urina-Jassir, Aneesh Dhore-patil, Thierry H. Le Jemtel, Hamid R. Alai   +4 more
core   +1 more source

Increased Disarray of Extracellular Matrix Collagen‐I Fiber Network and Compromised Biomechanics in Aortae From Marfan‐Syndrome Mice Assessed Through Combined Opto‐Biomechatronics

Advanced Science, EarlyView.
Combined structure‐function assessment in aortic rings from Marfan mice using MechaMorph Opto‐Biomechatronics technology relates increased elasticity (stiffness) and dynamic viscosity and less ordered extracellular matrix 3D‐structure (collagen) as potential causes for impaired Windkessel function and compromised haemodynamics in Marfan's syndrome ...
Dominik Schneidereit, Anika Nagel, Vanessa I. T. Zwaans, Laureen Schurr, Jonas Ahr, Michael Haug, Anna Piluso, Alexandra Sporkova, Matthias Karck, Andreas H. Wagner, Oliver Friedrich   +10 more
wiley   +1 more source

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source