Results 81 to 90 of about 179,384 (308)

Identifying Pathophysiological Mechanisms in Heart Failure With Reduced Versus Preserved Ejection Fraction [PDF]

, 2018
Background: Information on the pathophysiological differences between heart failure with reduced ejection fraction (HFrEF) versus heart failure with preserved ejection fraction (HFpEF) is needed Objectives: The purpose of this study was to establish ...
Anker, Stefan D., Cleland, John G. F., Dickstein, Kenneth, Filippatos, Gerasimos S., Hillege, Hans L., Lang, Chim, Metra, Marco, Ng, Leong Loke, Ouwerkerk, Wouter, Ponikowski, Piotr, Samani, Nilesh J., Tromp, Jasper, van der Harst, Pim, van der Meer, Peter, van Veldhuisen, Dirk Jan, Voors, Adriaan A., Westenbrink, Daan, Zannad, Faiez, Zwinderman, Aelko H.   +18 more
core   +3 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

A case report of a patient with heart failure with preserved ejection fraction presented as dysphagia

ESC Heart Failure, 2023
Dysphagia is a common clinical symptom in older people that can be attributed to a wide range of diseases, extending from neoplasm to gastroesophageal reflux diseases such as stroke or achalasia.
Elena Leonidou, Maria Ioannou, Petros Mavrommatis, Angeliki Mouzarou   +3 more
doaj   +1 more source

Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction.

Diabetes Care, 2022
OBJECTIVE To assess whether the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin improves cognitive impairment in frail older adults with diabetes and heart failure with preserved ejection fraction (HFpEF).
P. Mone, A. Lombardi, J. Gambardella, A. Pansini, Gaetano Macina, M. Morgante, Salvatore Frullone, G. Santulli   +7 more
semanticscholar   +1 more source

Cardiac metabolism — A promising therapeutic target for heart failure [PDF]

, 2017
Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF) are associated with high morbidity and mortality.
Frenneaux, Michael P, Loudon, Brodie L, Madhani, Melanie, Noordali, Hannah   +3 more
core   +2 more sources

Cold Atmospheric Plasma‐Activated Decellularized Extracellular Matrix Gel as a Tumor‐Infiltrating Immunoactivation Platform for Post‐Surgical Cancer Immunotherapy

Advanced Materials, EarlyView.
An injectable cold atmospheric plasma‐activated decellularized tumor extracellular matrix hydrogel is introduced as a post‐surgical immunoactivation platform. The engineered gel attracts residual tumor cells and induces immunogenic cell death, reshaping the tumor microenvironment and eliciting systemic antitumor immunity. In combination with checkpoint
Tianxu Fang, Mo Chen, Yueyang Deng, Tianqin Ning, Tianwen Luo, Guojun Chen   +5 more
wiley   +1 more source

Association of serum total bilirubin levels with diastolic dysfunction in heart failure with preserved ejection fraction

Biological Research, 2014
BACKGROUND: Left ventricular diastolic dysfunction is one of the main characteristics of heart failure patients with a preserved left ventricular ejection fraction.
Huan Zheng, Ye Li, Nanzi Xie
doaj   +1 more source

Management, survival, and predictors of mortality among hospitalized heart failure patients at Debre Markos comprehensive specialized hospital, Northwest Ethiopia: Prospective cohort study

SAGE Open Medicine, 2021
Introduction: Heart failure is a major public health problem worldwide. Since heart failure with reduced ejection fraction and preserved ejection fraction are different clinical entities, in-hospital mortality may occur at different rates.
Bekalu Kebede, Melese Getachew, Yalew Molla, Bereket Bahiru, Bekalu Dessie   +4 more
doaj   +1 more source

NAD+ Repletion Reverses Heart Failure With Preserved Ejection Fraction

Circulation Research, 2021
Supplemental Digital Content is available in the text. Rationale: Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies.
Dan Tong, G. Schiattarella, Nan Jiang, Francisco Altamirano, P. Szweda, Abdallah Elnwasany, Dong I. Lee, Heesoo Yoo, D. Kass, L. Szweda, S. Lavandero, E. Verdin, T. Gillette, Joseph A. Hill   +13 more
semanticscholar   +1 more source

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source