Results 101 to 110 of about 65,782,767 (266)

Static Drainage H2/O2 PEM Fuel Cells Enabled by Water Transport Plates: Pore‐Scale Design and Transport Mechanisms

Advanced Science, EarlyView.
The WTP is a key component of static drainage PEMFCs, enabling cathode water removal and gas sealing through capillary forces. This work investigates the mechanisms governing WTP drainage and sealing performance and develops predictive approaches for WTP design optimization.
Mengdi Guo, Diankai Qiu, Dong Zhu, Linfa Peng   +3 more
wiley   +1 more source

Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology [PDF]

, 2017
There is an unmet need for effective treatment strategies to reduce morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF).
Lam, Carolyn S P, Thomas M. Gorter, Heymans, Stephane, Wachter, Rolf, Barry A. Borlaug, Hill, Loreena, Rutten, Frans H., Tschoepe, Carsten, Mitja Lainscak, Marisa G. Crespo-Leiro, Lainscak, Mitja, Andrew J.S. Coats, Solomon, Scott D., Shah, Sanjiv J, Paulus, Walter J, Scott D. Solomon, Lund, Lars H, Tschöpe, Carsten, Christian Mueller, Stephane Heymans, Bauersachs, Johann, Walter J. Paulus, Gorter, Thomas M., Harjola, Veli-Pekka, Lyon, Alexander R., Rutten, Frans H, Marco Guazzi, Harjola, Veli Pekka, Celutkiene, Jelena, Coats, Andrew J S, Gorter, Thomas M, Ruschitzka, Frank, Massimo F. Piepoli, Rudolf A. de Boer, Piepoli, Massimo F, Seferovic, Petar M, Lam, Carolyn S.P., de Boer, Rudolf A, Lars H. Lund, van Veldhuisen, Dirk J, Carolyn S.P. Lam, Seferovic, Petar M., Veli-Pekka Harjola, Lund, Lars H., Petar M. Seferovic, Alexander R. Lyon, Carsten Tschöpe, Rolf Wachter, Triposkiadis, Filippos, Dirk J. van Veldhuisen, Johann Bauersachs, Mebazaa, Alexandre, Piepoli, Massimo F., Lam, Carolyn SP, Lam, Carolyn S. P., Paulus, Walter J., Coats, Andrew J.S., Mueller, Christian, Frank Ruschitzka, de Boer, Rudolf A., Borlaug, Barry A, Hill, Loreena; id_orcid, Filippos Triposkiadis, Sanjiv J. Shah, Coats, Andrew JS, Solomon, Scott D, Frans H. Rutten, van Veldhuisen, Dirk J., Crespo-Leiro, Marisa G, Shah, Sanjiv J., Burkert Pieske, Alexandre Mebazaa, Coats, Andrew J. S., Jelena Celutkiene, Crespo-Leiro, Marisa G., Loreena Hill, Borlaug, Barry A., Lyon, Alexander R, Pieske, Burkert, Guazzi, Marco   +79 more
core   +3 more sources

An Injectable, Self‐Expanding Hemostatic Foam for Field‐Compatible Postpartum Hemorrhage Management

Advanced Science, EarlyView.
Postpartum hemorrhage is the leading cause of maternal death worldwide, yet many treatments are hard to use outside well‐equipped hospitals. This work introduces an easy‐to‐use device that rapidly delivers a degradable foam into the uterus. The foam stops bleeding through pressure and clotting support, offering a practical option for low‐resource ...
Charlotte Meyer, Noël Strasser, Ilakkiya Ravindrarajah, Elsa Wrenger, Kristian Ivkovic, Jan Ševčík, Sima Šarčević, Lenka Červenková, Jáchym Rosendorf, Václav Liška, Alexandre H. Anthis, Thomas Rduch, Inge K. Herrmann   +12 more
wiley   +1 more source

Research Progress on Cardiac Energy Metabolic Changes in Heart Failure with Preserved Ejection Fraction [PDF]

Zhongguo quanke yixue
Heart failure with preserved ejection fraction (HFpEF) refers to a clinical syndrome characterized by a left ventricular ejection fraction of ≥50% and the presence of symptoms and clinical signs of heart failure.
MA Shuangshuang, XING Yanjiang, ZHANG Jiawei, WANG Jing
doaj   +1 more source

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

The value of exercise echocardiography in heart failure with preserved ejection fraction

Journal of Ultrasonography, 2019
Diastolic stress test is something that is now acknowledged in the recommendations and guidelines for diagnosing heart failure with preserved ejection fraction.
Erwan Donal
doaj   +1 more source

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Prognostic Value of Anxiety Between Heart Failure With Reduced Ejection Fraction and Heart Failure With Preserved Ejection Fraction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Evidence suggests differences in clinical characteristics, causes, and prognoses between heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF).
Tin‐Kwang Lin, Bo‐Cheng Hsu, Yi‐Da Li, Chi‐Hsien Chen, Jiunn‐Wen Lin, Chen‐Yu Chien, Chia‐Ying Weng   +6 more
doaj   +1 more source

Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications

Advanced Science, EarlyView.
Smart bioinks empower 4D‐bioprinted constructs to dynamically adapt and remodel in response to stimuli, effectively biomimicking native tissues. Artificial Intelligence (AI) and Machine Learning (ML) play a guiding role in their rational design by optimizing relevant properties.
Shangsi Chen, Jiahui Lai, Qiongjiao Zeng, Liangbin Zhou, Boguang Yang, Bin Zhang, Min Wang, Jiajing Zhou, Kieran Lau, Khoon S. Lim, Zhong Alan Li, Rocky S. Tuan   +11 more
wiley   +1 more source