Results 121 to 130 of about 65,782,767 (266)

Molecular Determinants and Clinical Characteristics of Heart Failure with Preserved Ejection Fraction

, 2019
Heart failure with preserved ejection fraction (HFpEF) accounts for approximately half of the diagnosed heart failure patients. In contrast to heart failure with reduced ejection fraction (HFrEF), there are currently no approved therapies for reducing ...
Lilford, Emilie Hédi
core  

Prior pacemaker implantation and clinical outcomes in patients with heart failure and preserved ejection fraction

, 2019
Objectives: This study examined the relationship between prior pacemaker implantation and clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF).
Anand, I. S., Swedberg, Karl, Petrie, M. C., Anand, Inder S., Jhund, P. S., Solomon, Scott D., Docherty, Kieran F., Carson, Peter E., Pfeffer, M. A., Petrie, Mark C., Zile, Michael R., Docherty, K. F., Granger, C. B., Zile, M. R., McMurray, J. J. V., Pfeffer, Marc A., Desai, A. S., Shen, Li, Swedberg, Karl,, McMurray, John J.V., Granger, Christopher B., Shen, L., McKelvie, Robert S., McKelvie, R. S., Solomon, S. D., Komajda, M., Desai, Akshay S., Komajda, Michel, Carson, P. E., Jhund, Pardeep S.   +29 more
core   +1 more source

Immigration detention centers as torturing environments: Ethical reckonings, radical refusals, and implications for a psychology of resistance

American Journal of Community Psychology, EarlyView.
Abstract This paper examines psychologists' ethical dilemmas in immigration detention centers. Using critical psychology, border, and detention scholarship, it highlights psychologists' historical complicity in state violence, from the U.S. Enhanced Interrogation Program to current border regimes.
Francesca Esposito, Federica de Cordova, Julia Manek, Sara Buckingham, Camilla Ponti, Francesco Tommasi, Bradley Olson   +6 more
wiley   +1 more source

A biomarker guided approach in heart failure [PDF]

, 2014
Heart failure is one of the commonest diagnoses presenting to physicians in the community or hospital care. Symptoms are often subjective, with clinicians having to rely on clinical assessment and radiological imaging to manage these patients.
Abela, Mark
core  

Refining a preclinical model of viral myocarditis in accordance with biotech standards

Animal Models and Experimental Medicine, EarlyView.
This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen, Julia Riedesel, Juliane Stein, Brandon H. Greene, Svenja Rohde, Sonja Suess, Bjoern Keiner, Priya Panjwani, Padmapriya Ponnuswamy, Juan E. Camacho Londoño   +9 more
wiley   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Silk Fibroin for Cardiovascular Medical Devices: Review of Material Properties, Applications, and Clinical Potential

Advanced NanoBiomed Research, EarlyView.
Silk fibroin is an attractive natural biomaterial that can be engineered into diverse cardiovascular constructs, including vascular grafts, cardiac patches, heart valves, and stent coatings. Its tunable biological and mechanical properties have driven substantial preclinical progress; however, widespread clinical translation in cardiovascular ...
Mahsa Haghighattalab, Matt Govendir, Kristina Andelovic, Zachary Och, Fatemeh Karimi, Munira Xaymardan, Tomasz Jungst, Jelena Rnjak‐Kovacina, Nona Farbehi   +8 more
wiley   +1 more source

Expert Perspective: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, Accepted Article.
Treat‐to‐target (T2T) has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal T2T framework for adult IIM has not yet been established.
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Cardiometabolic Phenotype in HFpEF: Insights from Murine Models

Biomedicines
Heart failure with preserved ejection fraction (HFpEF) remains a significant challenge in modern healthcare. It accounts for the majority of heart failure cases and their number worldwide is steadily increasing.
Ekaterina Ogurtsova, Tatiana Arefieva, Anastasiia Filatova, Natalya Radyukhina, Artem Ovchinnikov   +4 more
doaj   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source