Results 71 to 80 of about 163,785 (367)

Effects of empagliflozin on functional capacity, LV filling pressure, and cardiac reserves in patients with type 2 diabetes mellitus and heart failure with preserved ejection fraction: a randomized controlled open-label trial

Cardiovascular Diabetology
Background Clinical trials have established the prognostic benefits of sodium‒glucose cotransporter 2 (SGLT2) inhibitors in patients with type 2 diabetes mellitus (T2DM) and heart failure (HF) with preserved ejection fraction (HFpEF), although the ...
Artem Ovchinnikov, Alexandra Potekhina, Anastasiia Filatova, Olga Svirida, Kristina Zherebchikova, Fail Ageev, Evgeny Belyavskiy   +6 more
doaj   +1 more source

Tunable Thermoshrinkable Hydrogels for 4D Fabrication of Cell‐Seeded Channels

Advanced Functional Materials, EarlyView.
A thermoresponsive polymer with methacrylate groups for photo‐cross‐linking, based on polyethylene glycol, N‐isopropylacrylamide, and 2‐hydroxyethyl acrylate is synthetized to yield hydrogels that shrink upon temperature increase. The new polymer enables the fabrication of cell‐laden perfusable channels with diameters below 200 µm by combining ...
Greta Di Marco, Marc Falandt, Myriam Neumann, Martina Viola, Thibault Sampon, Marta G. Valverde, Anne Metje van Genderen, Silvia M. Mihaila, Cornelus F. van Nostrum, Bas G. P. van Ravensteijn, Riccardo Levato, Rosalinde Masereeuw, Tina Vermonden   +12 more
wiley   +1 more source

Heart Failure With Preserved Ejection Fraction and Obesity

JACC: Case Reports, 2020
This report describes a case of heart failure with preserved ejection fraction in a post-menopausal woman with obesity. The case highlights a metabolic phenotype of heart failure with preserved ejection fraction that commonly manifests in women, with the
Arjun Sinha, MD, Clyde W. Yancy, MD, Sanjiv J. Shah, MD, Sadiya S. Khan, MD   +3 more
doaj   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

Automated echocardiographic detection of heart failure with preserved ejection fraction using artificial intelligence [PDF]

, 2023
Background: Detection of heart failure with preserved ejection fraction (HFpEF) involves integration of multiple imaging and clinical features which are often discordant or indeterminate. Objectives: We applied artificial intelligence (AI) to analyze a
Akerman, A.P., Akerman, A.P., Arystan, A.Z., Arystan, A.Z., Beqiri, A., Beqiri, A., Chartsiad, A., Chartsiad, A., Hawkes, W., Hawkes, W., Huntley, G.D., Huntley, G.D., Kane, G.C., Kane, G.C., Leeson, P., Leeson, P., Lopez-Jimenez, F., Lopez-Jimenez, F., O'Driscoll, J., O'Driscoll, J., Pellikka, P.A., Pellikka, P.A., Pislaru, S.V., Pislaru, S.V., Porumb, M., Porumb, M., Ryu, A.J., Ryu, A.J., Sarwar, R., Sarwar, R., Scott, C.G., Scott, C.G., Upton, R., Upton, R., Woodward, G., Woodward, G.   +35 more
core   +1 more source

Empagliflozin Improves Cognitive Impairment in Frail Older Adults With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction.

Diabetes Care, 2022
OBJECTIVE To assess whether the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin improves cognitive impairment in frail older adults with diabetes and heart failure with preserved ejection fraction (HFpEF).
P. Mone, A. Lombardi, J. Gambardella, A. Pansini, Gaetano Macina, M. Morgante, Salvatore Frullone, G. Santulli   +7 more
semanticscholar   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

A case report of a patient with heart failure with preserved ejection fraction presented as dysphagia

ESC Heart Failure, 2023
Dysphagia is a common clinical symptom in older people that can be attributed to a wide range of diseases, extending from neoplasm to gastroesophageal reflux diseases such as stroke or achalasia.
Elena Leonidou, Maria Ioannou, Petros Mavrommatis, Angeliki Mouzarou   +3 more
doaj   +1 more source

Hierarchically MOF‐Based Porous Monolith Composites for Atmospheric Water Harvesting

Advanced Materials, EarlyView.
This review explores the design of hierarchical porous materials for atmospheric water harvesting, focusing on metal‐organic frameworks (MOFs) and porous monoliths. Emphasis is placed on integrating MOF nanoscale porosity with the microscale channels of monolithic scaffolds to enhance sorption‐desorption performance.
Mahyar Panahi‐Sarmad, Tianyu Guo, Seyyed Alireza Hashemi, Ahmadreza Ghaffarkhah, Stefan Wuttke, Mohammad Arjmand, Orlando J. Rojas, Feng Jiang   +7 more
wiley   +1 more source

Management, survival, and predictors of mortality among hospitalized heart failure patients at Debre Markos comprehensive specialized hospital, Northwest Ethiopia: Prospective cohort study

SAGE Open Medicine, 2021
Introduction: Heart failure is a major public health problem worldwide. Since heart failure with reduced ejection fraction and preserved ejection fraction are different clinical entities, in-hospital mortality may occur at different rates.
Bekalu Kebede, Melese Getachew, Yalew Molla, Bereket Bahiru, Bekalu Dessie   +4 more
doaj   +1 more source