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Heart Failure With Reduced Ejection Fraction [PDF]
JAMA, 2020 Worldwide, the burden of heart failure has increased to an estimated 23 million people, and approximately 50% of cases are HF with reduced ejection fraction (HFrEF).Heart failure is a clinical syndrome characterized by dyspnea or exertional limitation due to impairment of ventricular filling or ejection of blood or both.
James L. Januzzi +2 more
semanticscholar +9 more sources
Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction [PDF]
New England Journal of Medicine, 2019 In patients with type 2 diabetes, inhibitors of sodium-glucose cotransporter 2 (SGLT2) reduce the risk of a first hospitalization for heart failure, possibly through glucose-independent mechanisms. More data are needed regarding the effects of SGLT2 inhibitors in patients with established heart failure and a reduced ejection fraction, regardless of the
Mikhail Kosiborod +40 more
semanticscholar +14 more sources
Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction
New England Journal of Medicine, 2020 The effect of vericiguat, a novel oral soluble guanylate cyclase stimulator, in patients with heart failure and reduced ejection fraction who had recently been hospitalized or had received intravenous diuretic therapy is unclear.In this phase 3, randomized, double-blind, placebo-controlled trial, we assigned 5050 patients with chronic heart failure ...
Armstrong, Paul W +16 more
openaire +9 more sources
Use of angiotensin receptor – neprilysin inhibitors in heart failure: a paradigm shift [PDF]
South African Family Practice, 2016 Heart failure is a clinical syndrome responsible for at least one-third of hospitalisations amongst cardiac patients, with escalating mortality and healthcare costs on both public and private health care.
M. O.E. Irhuma, M. Vally
doaj +3 more sources
Neurohormonal activation in heart failure with reduced ejection fraction [PDF]
Nature Reviews Cardiology, 2016 Heart failure with reduced ejection fraction (HFrEF) develops when cardiac output falls as a result of cardiac injury. The most well-recognized of the compensatory homeostatic responses to a fall in cardiac output are activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS).
Justin Hartupee, Douglas L. Mann
openaire +4 more sources
ESC Heart Failure, 2023 Aims This study aimed to investigate the prognostic value of dynamic changes in left ventricular ejection fraction (EF) for cardiovascular (CV) outcomes in an all‐comer heart failure (HF) population with reduced EF (HFrEF, EF 4 vs.
Dan Liu +7 more
doaj +3 more sources
Clinical Utility of Exercise Training in Heart Failure with Reduced and Preserved Ejection Fraction [PDF]
, 2015 Reduced exercise tolerance is an independent predictor of hospital readmission and mortality in patients with heart failure (HF). Exercise training for HF patients is well established as an adjunct therapy, and there is sufficient evidence to support the
Muhammad Asrar ul Haq +4 more
openalex +5 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background Evidence suggests differences in clinical characteristics, causes, and prognoses between heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF).
Tin‐Kwang Lin +6 more
doaj +4 more sources
Distinguishing heart failure with reduced ejection fraction from heart failure with preserved ejection fraction: A phenomics approach [PDF]
European Journal of Heart FailureAbstractAimPathophysiological differences between patients with heart failure with preserved (HFpEF) and reduced (HFrEF) ejection fraction (EF) remain unclear. Therefore we used a phenomics approach, integrating selected proteomics data with patient characteristics and cardiac structural and functional parameters, to get insight into differential ...
Van Essen, Bart J +20 more
openaire +6 more sources
Interpretation of the Essential Updates in 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure [PDF]
Zhongguo quanke yixue, 2022 The American Heart Association (AHA) , American College of Cardiology (ACC) and Heart Failure Society of America (HFSA) jointly released the 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure (hereinafter referred to as the 2022 Guideline) .
Yifang GUO
doaj +1 more source