Results 91 to 100 of about 2,227,737 (406)

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure—Results From the MyoVasc Study

Frontiers in Cardiovascular Medicine, 2021
Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH)
Bianca Dahlen, Felix Müller, Felix Müller, Sven-Oliver Tröbs, Sven-Oliver Tröbs, Sven-Oliver Tröbs, Marc William Heidorn, Marc William Heidorn, Andreas Schulz, Natalie Arnold, Natalie Arnold, M. Iris Hermanns, Sören Schwuchow-Thonke, Jürgen H. Prochaska, Jürgen H. Prochaska, Jürgen H. Prochaska, Tommaso Gori, Tommaso Gori, Hugo ten Cate, Karl J. Lackner, Karl J. Lackner, Thomas Münzel, Thomas Münzel, Philipp S. Wild, Philipp S. Wild, Philipp S. Wild, Marina Panova-Noeva, Marina Panova-Noeva   +27 more
doaj   +1 more source

Cost‐effectiveness of dapagliflozin as a treatment for heart failure with reduced ejection fraction: a multinational health‐economic analysis of DAPA‐HF

European Journal of Heart Failure, 2020
To estimate the cost‐effectiveness of dapagliflozin added to standard therapy, vs. standard therapy only, in patients with heart failure (HF) with reduced ejection fraction (HFrEF), from the perspective of UK, German, and Spanish payers.
P. McEwan, O. Darlington, J. McMurray, P. Jhund, K. Docherty, M. Böhm, M. Petrie, K. Bergenheim, Lei Qin   +8 more
semanticscholar   +1 more source

Association between dosing and combination use of medications and outcomes in heart failure with reduced ejection fraction: data from the Swedish Heart Failure Registry

European Journal of Heart Failure, 2022
To assess the association between combination, dose and use of current guideline‐recommended target doses (TD) of renin–angiotensin system inhibitors (RASi), angiotensin receptor–neprilysin inhibitors (ARNi) and β‐blockers, and outcomes in a large and ...
D. D’Amario, Daniele Rodolico, G. Rosano, U. Dahlström, F. Crea, L. Lund, G. Savarese   +6 more
semanticscholar   +1 more source

Novel Biologically Active Glass Fiber Functionalized Using Magnesium Phosphate Cement Promotes Bone and Vascular Regeneration

Advanced Biology, EarlyView.
In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu, Yanbo Shan, Yingjie Xiong, Jianting Ye, Yanbin Wu, Jipeng Song, Yao Zhang, Wancheng Lin, Haoye Meng, Wenjing Xu, Jiang Peng, Qiang Lu, Lixiang Ding   +12 more
wiley   +1 more source

EchoGNN: Explainable Ejection Fraction Estimation with Graph Neural Networks [PDF]

arXiv, 2022
Ejection fraction (EF) is a key indicator of cardiac function, allowing identification of patients prone to heart dysfunctions such as heart failure. EF is estimated from cardiac ultrasound videos known as echocardiograms (echo) by manually tracing the left ventricle and estimating its volume on certain frames.
arxiv  

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Heart failure with preserved ejection fraction: an update on pathophysiology, diagnosis, treatment, and prognosis

Brazilian Journal of Medical and Biological Research
Heart failure (HF) with preserved ejection fraction (HFpEF) is a clinical syndrome in which patients have symptoms and signs of HF with normal or near-normal left ventricular ejection fraction (LVEF ≥50%).
Chao Ma, Huan Luo, Lei Fan, Xiaoyan Liu, Chengshan Gao   +4 more
doaj   +1 more source

Cyclical Self-Supervision for Semi-Supervised Ejection Fraction Prediction from Echocardiogram Videos [PDF]

arXiv, 2022
Left-ventricular ejection fraction (LVEF) is an important indicator of heart failure. Existing methods for LVEF estimation from video require large amounts of annotated data to achieve high performance, e.g. using 10,030 labeled echocardiogram videos to achieve mean absolute error (MAE) of 4.10.
arxiv  

Heart failure with mid-range or mildly reduced ejection fraction

Nature Reviews Cardiology, 2021
Left ventricular ejection fraction (EF) remains the major parameter for diagnosis, phenotyping, prognosis and treatment decisions in heart failure. The 2016 ESC heart failure guidelines introduced a third EF category for an EF of 40–49%, defined as heart
G. Savarese, D. Stolfo, G. Sinagra, L. Lund   +3 more
semanticscholar   +1 more source