Advanced Science, EarlyView.An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang +8 more
wiley +1 more source
Acute Gangrenous Cholecystitis During Pregnancy: A Case Report. [PDF]
Case Rep SurgSoeur C.
europepmc +1 more source
Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer
Advanced Science, EarlyView.In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen +10 more
wiley +1 more source
Exercise in pregnant elite athletes: Physiological considerations, risks, and benefits. [PDF]
Physiol RepMadera I +5 more
europepmc +1 more source
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
Agreement between cardiac cycle time intervals and myocardial velocities measured by automated analysis of color tissue Doppler cine loops and by manual tracing of spectral pulsed-wave tissue Doppler waveforms of sheep fetal heart under normal and pathological conditions: An experimental study. [PDF]
Acta Obstet Gynecol ScandLantto J +6 more
europepmc +1 more source
Effect of oxytocin injection on fetal heart rate based on multifractal analysis
Background: Oxytocin is a short acting drug, which needs continuous intravenous drip to maintain the effect of uterine contraction. Excessive uterine contraction may lead to abnormal blood supply of fetal placenta and fetal hypoxia.
Kim, Junseok +4 more
core
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies MZF1 as a core regulator of colon cancer via SnoN‐mediated TGF‐β suppression, proposes 10Panx Acetate as a targeted inhibitor, and validates MZF1/SnoN as prognostic markers for aggressive disease. ABSTRACT Colon cancer progression is associated with transcriptional and signaling abnormalities.
Siqi Sheng +9 more
wiley +1 more source
Fetal heart rate patterns associated with acidemia at fetal blood sampling during labor-An observational study. [PDF]
Acta Obstet Gynecol ScandGyllencreutz E +4 more
europepmc +1 more source