Results 151 to 160 of about 2,228,463 (350)

Regional Distribution of Diffusible Tracers and Carbonized Microspheres in the Left Ventricle of Isolated Dog Hearts [PDF]

, 1973
Tada Yipintsoi, William A. Dobbs, Paul D. Scanlon, T. J. Knopp, James B. Bassingthwaighte   +4 more
openalex   +1 more source

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Cross-sectional echocardiography in the diagnosis of congenital heart disease. Identification of the relation of the ventricles and great arteries. [PDF]

, 1977
Walter L. Henry, B J Maron, Jim Griffith
openalex   +1 more source

Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis

Advanced Science, EarlyView.
This study presents decursin, a traditional Chinese medicine monomer, that inhibits lipid accumulation and inflammation in atherosclerosis through PKCδ interaction. A novel targeted delivery system (ALD@EM) is developed to overcome decursin's short half‐life, combining antibody‐mediated targeting, LDL‐facilitated chemotaxis, and enhanced macrophage ...
Hui Chen, Yifeng Zhang, Mirenuer Aikebaier, Yawei Du, Yan Liu, Qing Zha, Lan Zheng, Shuyao Shan, Yanping Wang, Jiawei Chen, Yiping Li, Ke Yang, Ying Yang, Wenguo Cui   +13 more
wiley   +1 more source

Regulatory effect of gut microbes on blood pressure

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 513-531, December 2022., 2022
The interaction between gut microbiota and hypertension, the genera which affect the blood pressure in taxonomic level, and the commonly used treatments to hypertension based on the gut microbes were summarized in this review. The increases of Lactobacillus, etc.
Dong Yan, Ye Sun, Xiaoyue Zhou, Wenhao Si, Jieyu Liu, Min Li, Minna Wu   +6 more
wiley   +1 more source

Lost in Tracking: Uncertainty-guided Cardiac Cine MRI Segmentation at Right Ventricle Base [PDF]

Accurate biventricular segmentation of cardiac magnetic resonance (CMR) cine images is essential for the clinical evaluation of heart function. However, compared to left ventricle (LV), right ventricle (RV) segmentation is still more challenging and less reproducible.
arxiv   +1 more source

Effects of open heart surgery on end-diastolic pressure-diameter relations of the human left ventricle. [PDF]

, 1979
Henry M. Spotnitz, David Bregman, Frederick O. Bowman, Richard N. Edie, K Reemtsma, DL King, Brian F. Hoffman, James R. Malm   +7 more
openalex   +1 more source

Leucine‐Rich Repeat‐Containing G Protein‐Coupled Receptor 6 Ameliorates Pressure Overload‐Induced Cardiac Hypertrophy by Regulating Cardiomyocyte Metabolic Reprogramming

Advanced Science, EarlyView.
LGR6 overexpression ameliorates cardiac hypertrophy by regulating metabolic reprogramming through USP4‐PPARα pathway. Abstract Metabolic reprogramming is a pivotal mechanism in the pathogenesis of pathological cardiac hypertrophy. Leucine‐rich repeat‐containing G protein‐coupled receptor 6 (Lgr6) has emerged as a significant player in cardiovascular ...
Mengmeng Zhao, Jianfang Liu, Shanshan Peng, Zihui Zheng, Siqi Liu, Jun Wan, Yao Xu, Menglong Wang   +7 more
wiley   +1 more source

To unwind the biological knots: The DNA/RNA G‐quadruplex resolvase RHAU (DHX36) in development and disease

Animal Models and Experimental Medicine, Volume 5, Issue 6, Page 542-549, December 2022., 2022
Schematic diagram showing RHAU can bind and unwind the G4 “knots” to modulate embryonic development and post‐natal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis and organ dysfunction. RHAU modulates Nkx2‐5 mRNA and Yap1 mRNA at the post‐transcriptional level and facilitates the transcription of c‐Kit and ...
Chensi Yang, Jie Yao, Huijuan Yi, Xinyi Huang, Wukui Zhao, Zhongzhou Yang   +5 more
wiley   +1 more source

Geodesic-based Predictive Shape Modeling on Right Ventricles of Patients with Hypoplastic Left Heart Syndrome [PDF]

arXiv
Hypoplastic left heart syndrome (HLHS) is a congenital defect in which right ventricle (RV) shape changes over time in response to altered loading conditions as adaptations to patient's single ventricle physiology. The RV shape can be considered as a co-indicator of the severity of underlying tricuspid valve (TV) regurgitation in HLHS, thus the ...
arxiv