Results 161 to 170 of about 2,557,215 (346)

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Movements of Ca in frog heart ventricles at rest and during contractures

Journal of Physiology, 1963
R. Niedergerke
semanticscholar   +1 more source

Brown Adipocyte Sheets Alleviate Myocardial Ischemia–Reperfusion Injury Through NRG4–ErbB4–Dependent Ferroptosis Inhibition

Advanced Science, EarlyView.
Brown adipocyte sheets are engineered to protect the heart against myocardial ischemia–reperfusion injury by restraining ferroptosis. Upon transplantation onto the cardiac surface, they improve cardiac function, limit infarction and fibrosis, and enhance angiogenesis.
Lifu Sun, Yuting Liu, Jingbo Zhang, Takuji Kawamura, Junjun Li, Li Liu, Shigeru Miyagawa   +6 more
wiley   +1 more source

Heart wound (left ventricle)

, 2020
Presented at session 7th August ...
Larghero Ibarz, Pedro, Otero, José P
openaire   +1 more source

Topologically Structured PLLA Fibers With Stress Concentration Effects for Health Monitoring

Advanced Science, EarlyView.
In this study, a multi‐path strategy was developed to enhance the piezoelectric properties of PLLA fibers through the stress concentration effect. The optimized devices generate piezoelectric output up to 14 times that of pure PLLA fibers. This piezoelectric enhancement strategy offers a new approach for high‐performance piezoelectric devices, with ...
Longfei Li, Juwei Yang, Yiqian Wang, Qiao Yu, Zhenmin Fan, Chang Zhu, Ming Yin, Wei Hua, Zhou Li   +8 more
wiley   +1 more source

Increased Angiotensin-(1-7)–Forming Activity in Failing Human Heart Ventricles: Evidence for Upregulation of the Angiotensin-Converting Enzyme Homologue ACE2

Circulation, 2003
Lawrence S. Zisman, R. Keller, B. Weaver, Q. Lin, R. Speth, M. Bristow, C. Canver   +6 more
semanticscholar   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Left and right ventricular tissue velocities are reduced in hypertrophic cardiomyopathy but not in athlete's heart

, 2008
Left ventricular hypertrophy due to athlete’s heart and hypertrophic cardiomyopathy (HCM) can be difficult to distinguish clinically and can affect both ventricles.
Francis, JM, Hudsmith, LE, Watkins, H, Neubauer, S, Petersen, SE, Ali, M, Robson, MD, Jerosch-Herold, M, Young, Alistair, Markl, M   +9 more
core  

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Blocks of the heart (AV blocks)

, 2015
Heart block is an abnormal heart rhythm where the heart beats too slowly (bradycardia). In this condition, the electrical signals that tell the heart to contract are partially or totally blocked between the atria and the ventricles.
Ahmed, Sahban Rasheed, Кочубей, Оксана Анатольевна, Кочубєй, Оксана Анатоліївна, Kochubiei, Oksana   +3 more
core