Results 161 to 170 of about 130,285 (357)

SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, EarlyView.
SpaBatch is an end‐to‐end multi‐slice spatial transcriptomics data integration framework. It simultaneously performs embedding learning, spatial feature denoising and reconstruction, batch effect correction, and spatial domain optimization, effectively correcting batch effects and achieving accurate 3D spatial domain identification.
Jinyun Niu   +5 more
wiley   +1 more source

Rationally Designed TadA‐Derived Cytosine Editors Enable Context‐Independent Zebrafish Genome Editing

open access: yesAdvanced Science, EarlyView.
A next‐generation cytosine base editor (zTadCBE) and other variants are developed by combining the high‐efficiency (TadCBEa) and low‐indel (TadCBEMax) architectures, followed by the introduction of zebrafish‐optimized mutations (V82S, Q154R) in the TadA domain.
Wei Qin   +7 more
wiley   +1 more source

Is resynchronization between left and right ventricles responsible for improving hemodynamic function of heart failure patients with LBBB? [PDF]

open access: bronze, 2000
Yang Yu   +6 more
openalex   +1 more source

Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review

open access: yesAdvanced Science, EarlyView.
Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao   +4 more
wiley   +1 more source

Inotropic effect of some membranotropic agents on isolated right ventricle of rat heart [PDF]

open access: bronze, 2000
Maja Pavlović   +5 more
openalex   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

open access: yesAdvanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian   +7 more
wiley   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

open access: yesAdvanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen   +11 more
wiley   +1 more source

Distribution of the Muscarinic K+ Channel Proteins Kir3.1 and Kir3.4 in the Ventricle, Atrium, and Sinoatrial Node of Heart [PDF]

open access: bronze, 2001
Halina Dobrzynski   +8 more
openalex   +1 more source

Microgel Aspect Ratio Influences Injectable Granular Hydrogel Scaffold Pore Structure and Cellular Invasion for Tissue Repair

open access: yesAdvanced Science, EarlyView.
Granular hydrogels are being developed for the repair of tissues, mostly with the use of spherical microgels. Here, injectable granular hydrogels formed from anisotropic particles (i.e., rod‐like) are explored to improve cellular invasion by increasing scaffold void volume fraction.
Gabriel J. Rodriguez‐Rivera   +11 more
wiley   +1 more source

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