Results 21 to 30 of about 7,536 (189)

Focal persistence and phylodynamics of Heartland virus in Georgia. [PDF]

Virus Evol
Abstract Heartland virus (HRTV) is an emerging tick-borne virus associated with severe illness in the USA. There are large gaps in knowledge of HRTV diversity, evolution, and transmission due to a paucity of HRTV-positive samples and genome sequences.
Bellman S, Shariatzadeh N, Ferrell T, Long A, Aeschleman L, Fausett E, Walsh T, Cleary S, Roeske I, Ojeda E, Schwab M, Dakanay H, Telford Iii SR, Goethert HK, Vazquez-Prokopec G, Piantadosi A.   +15 more
europepmc   +4 more sources

Safety, Immunogenicity, and Efficacy of a Recombinant Vesicular Stomatitis Virus Vectored Vaccine Against Severe Fever with Thrombocytopenia Syndrome Virus and Heartland Bandavirus [PDF]

Vaccines
Background: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a recently emerged tickborne virus in east Asia with over 18,000 confirmed cases.
Philip Hicks, Tomaz B. Manzoni, Jonna B. Westover, Raegan J. Petch, Brianne Roper, Brian B. Gowen, Paul Bates   +6 more
doaj   +5 more sources

Novel Clinical and Pathologic Findings in a Heartland Virus-Associated Death. [PDF]

Clin Infect Dis, 2017
Abstract We describe an investigation into a Heartland virus (HRTV)–associated death in Tennessee with novel clinical and pathologic findings. HRTV can cause rapidly fatal, widely disseminated infection with multisystem organ failure in patients without substantial comorbidities.
Fill MA, Compton ML, McDonald EC, Moncayo AC, Dunn JR, Schaffner W, Bhatnagar J, Zaki SR, Jones TF, Shieh WJ.   +9 more
europepmc   +5 more sources

The Cap-Snatching SFTSV Endonuclease Domain Is an Antiviral Target [PDF]

Cell Reports, 2020
Summary: Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne virus with 12%–30% case mortality rates and is related to the Heartland virus (HRTV) identified in the United States.
Wenjie Wang, Woo-Jin Shin, Bojie Zhang, Younho Choi, Ji-Seung Yoo, Maxwell I. Zimmerman, Thomas E. Frederick, Gregory R. Bowman, Michael L. Gross, Daisy W. Leung, Jae U. Jung, Gaya K. Amarasinghe   +11 more
doaj   +3 more sources

First detection of heartland virus (Bunyaviridae: Phlebovirus) from field collected arthropods. [PDF]

Am J Trop Med Hyg, 2013
Heartland virus (HRTV), the first pathogenic Phlebovirus (Family: Bunyaviridae) discovered in the United States, was recently described from two Missouri farmers. In 2012, we collected 56,428 ticks representing three species at 12 sites including both patients' farms.
Savage HM, Godsey MS, Lambert A, Panella NA, Burkhalter KL, Harmon JR, Lash RR, Ashley DC, Nicholson WL.   +8 more
europepmc   +6 more sources

Development and Characterization of Monoclonal Antibodies Directed Against the Nucleoprotein of Heartland Virus. [PDF]

Am J Trop Med Hyg, 2015
Heartland virus (HRTV), a phlebovirus first isolated from two Missouri farmers in 2009, has been proposed to be transmitted to humans by the bite of infected Amblyomma americanum ticks. It is closely related to severe fever with thrombocytopenia syndrome virus (SFTSV) from China, another previously unrecognized phlebovirus that has subsequently been ...
Calvert AE, Brault AC.
europepmc   +6 more sources

Heartland Virus Exposure in White-Tailed Deer in the Southeastern United States, 2001-2015. [PDF]

Am J Trop Med Hyg, 2018
Heartland virus (HRTV) is a North American phlebovirus suspected to be transmitted by the lone star tick Amblyomma americanum. White-tailed deer (WTD) have been shown to develop HRTV-neutralizing antibodies following experimental infection. To further define the geographic distribution of HRTV through retrospective sampling of WTD, sera from the WTD ...
Clarke LL, Ruder MG, Mead DG, Howerth EW.   +3 more
europepmc   +6 more sources

A novel tick-borne phlebovirus, closely related to severe fever with thrombocytopenia syndrome virus and Heartland virus, is a potential pathogen. [PDF]

Emerg Microbes Infect, 2018
Tick-borne viral diseases have attracted much attention in recent years because of their increasing incidence and threat to human health. Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV) and Heartland virus (HRTV) were recently identified as tick-borne phleboviruses (TBPVs) in Asia and the United States, respectively, and are associated ...
Shen S, Duan X, Wang B, Zhu L, Zhang Y, Zhang J, Wang J, Luo T, Kou C, Liu D, Lv C, Zhang L, Chang C, Su Z, Tang S, Qiao J, Moming A, Wang C, Abudurexiti A, Wang H, Hu Z, Zhang Y, Sun S, Deng F.   +23 more
europepmc   +5 more sources

Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine. [PDF]

J Virol
ABSTRACT Heartland virus (HRTV) is an emerging tick-borne bandavirus that causes a febrile illness of varying severity in humans, with cases reported in eastern and midwestern regions of the United States. No vaccines or approved therapies are available to prevent or treat HRTV disease.
Westover JB, Jung KH, Alkan C, Boardman KM, Van Wettere AJ, Martens C, Rojas I, Hicks P, Thomas AJ, Saindane MT, Bluemling GR, Mao S, Kolykhalov AA, Natchus MG, Bates P, Painter GR, Ikegami T, Gowen BB.   +17 more
europepmc   +5 more sources

Prevalence of Bourbon and Heartland viruses in field collected ticks at an environmental field station in St. Louis County, Missouri, USA

Ticks and Tick-Borne Diseases, 2023
Heartland and Bourbon viruses are pathogenic tick-borne viruses putatively transmitted by Amblyomma americanum, an abundant tick species in Missouri. To assess the prevalence of these viruses in ticks, we collected 2778 ticks from eight sampling sites at
Ishmael D. Aziati, Derek McFarland Jnr, Avan Antia, Astha Joshi, Anahi Aviles-Gamboa, Preston Lee, Houda Harastani, David Wang, Solny A. Adalsteinsson, Adrianus C.M. Boon   +9 more
doaj   +2 more sources