Modeling Heartland virus disease in mice and therapeutic intervention with 4'-fluorouridine. [PDF]
J VirolHeartland virus (HRTV) is an emerging tick-borne bandavirus that causes a febrile illness of varying severity in humans, with cases reported in eastern and midwestern regions of the United States.
Westover JB +17 more
europepmc +6 more sources
Heartland Virus and Hemophagocytic Lymphohistiocytosis in Immunocompromised Patient, Missouri, USA [PDF]
Emerging Infectious Diseases, 2018 Heartland virus is a suspected tickborne pathogen in the United States. We describe a case of hemophagocytic lymphohistiocytosis, then death, in an immunosuppressed elderly man in Missouri, USA, who was infected with Heartland virus.
Abigail L. Carlson +14 more
doaj +7 more sources
The Lone Star tick, Amblyomma americanum, salivary factors exacerbate the clinical outcome of Heartland virus disease in a small animal model [PDF]
Scientific Reports, 2023 Heartland virus was first isolated in 2009 from two patients in Missouri and is transmitted by the Lone Star tick, Amblyomma americanum. To understand disease transmission and pathogenesis, it is necessary to develop an animal model which utilizes the ...
Erin S. Reynolds +3 more
doaj +5 more sources
Experimental Infection of White-Tailed Deer (Odocoileus virginanus) with Heartland Virus. [PDF]
Am J Trop Med Hyg, 2018 Heartland virus (HRTV) is a phlebovirus suspected to be transmitted by Amblyomma americanum, commonly known as the lone star tick, and reported to cause illness in humans, which is characterized by thrombocytopenia and leukopenia.
Clarke LL, Ruder MG, Mead D, Howerth EW.
europepmc +7 more sources
A panel of real-time PCR assays for the detection of Bourbon virus, Heartland virus, West Nile virus, and Trypanosoma cruzi in major disease-transmitting vectors. [PDF]
J Vet Diagn Invest, 2021 Vector-borne pathogens, such as Bourbon virus (BRBV), Heartland virus (HRTV), West Nile virus (WNV), and Trypanosoma cruzi (TCZ) are a great threat to public health and animal health.
Warang A, Zhang M, Zhang S, Shen Z.
europepmc +7 more sources
Heartland Virus Exposure in White-Tailed Deer in the Southeastern United States, 2001-2015. [PDF]
Am J Trop Med Hyg, 2018 Heartland virus (HRTV) is a North American phlebovirus suspected to be transmitted by the lone star tick Amblyomma americanum. White-tailed deer (WTD) have been shown to develop HRTV-neutralizing antibodies following experimental infection.
Clarke LL +3 more
europepmc +8 more sources
Development and Characterization of Monoclonal Antibodies Directed Against the Nucleoprotein of Heartland Virus. [PDF]
Am J Trop Med Hyg, 2015 Heartland virus (HRTV), a phlebovirus first isolated from two Missouri farmers in 2009, has been proposed to be transmitted to humans by the bite of infected Amblyomma americanum ticks. It is closely related to severe fever with thrombocytopenia syndrome
Calvert AE, Brault AC.
europepmc +8 more sources
Novel Clinical and Pathologic Findings in a Heartland Virus-Associated Death. [PDF]
Clin Infect Dis, 2017 Abstract We describe an investigation into a Heartland virus (HRTV)–associated death in Tennessee with novel clinical and pathologic findings. HRTV can cause rapidly fatal, widely disseminated infection with multisystem organ failure in patients without substantial comorbidities.
Fill MA +9 more
europepmc +7 more sources
The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae. [PDF]
J Virol, 2018 ABSTRACT Heartland virus (HRTV) is an emerging human pathogen that belongs to the newly defined family Phenuiviridae , order Bunyavirales . Gn and Gc are two viral surface glycoproteins encoded by the M segment and are required for early events during infection.
Zhu Y +6 more
europepmc +8 more sources
Secondary hemophagocytic lymphohistiocytosis due to Heartland virus. [PDF]
BMJ Case Rep, 2022 An older man from the mid-Southeastern USA presented with acute onset of fever, fatigue, and non-bloody diarrhoea. There was high suspicion for tick-borne illness given exposure history, clinical presentation and laboratory abnormalities.
Ahlers CG +3 more
europepmc +4 more sources