Heartland virus: a novel and emerging tick-borne encephalitis
Revista MVZ Córdoba, 2016 Heartland virus (HRTV) is a Bunyaviridae, phlebovirus that it has recently emerged as the causative agent of human disease characterized by thrombocytopenia and leukopenia in the United States and China. It seems to be the HRTV has been also reported in China, Japan and Korea.
Salim Mattar V., Marco González T
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Investigation of Heartland Virus Disease Throughout the United States, 2013-2017. [PDF]
Open Forum Infect Dis, 2020 Abstract Background Heartland virus (HRTV) was first described as a human pathogen in 2012. From 2013 to 2017, the Centers for Disease Control and Prevention (CDC) implemented a national protocol to evaluate patients for HRTV disease, better define its geographic distribution, epidemiology, and ...
Staples JE +8 more
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Heartland virus NSs protein disrupts host defenses by blocking the TBK1 kinase-IRF3 transcription factor interaction and signaling required for interferon induction. [PDF]
J Biol Chem, 2017 Ning YJ +5 more
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Development of diagnostic microsphere-based immunoassays for Heartland virus
Journal of Clinical Virology, 2020 Heartland virus (HRTV), a recently reclassified member of the genus Bandavirus, family Phenuiviridae, was first isolated in 2009 from a Missouri farmer exhibiting leukopenia and thrombocytopenia with suspected ehrlichiosis. Since then, more HRTV cases have been diagnosed, and firstline laboratory diagnostic assays are needed to identify future ...
Alison Jane Basile +9 more
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Experimental Infection of White-Tailed Deer (Odocoileus virginanus) with Heartland Virus. [PDF]
Am J Trop Med Hyg, 2018 Heartland virus (HRTV) is a phlebovirus suspected to be transmitted by Amblyomma americanum, commonly known as the lone star tick, and reported to cause illness in humans, which is characterized by thrombocytopenia and leukopenia. Heartland virus–reactive antibodies have been detected in a variety of wildlife species including white-tailed deer (WTD ...
Clarke LL, Ruder MG, Mead D, Howerth EW.
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Dermatological manifestations of tick-borne viral infections found in the United States
Virology Journal, 2022 Tick-borne diseases (TBDs) are bacterial, viral, and parasitic diseases transmitted by ticks. Viral TBDs have increased in prevalence over the last decade with many new pathogenic viruses being discovered.
Ammie Rupani +2 more
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Lethal Case of Bourbon Virus Leading to Shock and ECMO Utilization. [PDF]
Case Rep Infect DisWe present a lethal case of Bourbon virus infection in a 63‐year‐old Caucasian, diabetic male who was previously in good health. The patient had spent time in the wooded areas of Bourbon County, Kansas, and removed three ticks from his body 5 days prior to presentation.
Mitchell A +6 more
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Metagenomic-based Surveillance of Pacific Coast tick Dermacentor occidentalis Identifies Two Novel Bunyaviruses and an Emerging Human Ricksettsial Pathogen. [PDF]
, 2017 An increasing number of emerging tick-borne diseases has been reported in the United States since the 1970s. Using metagenomic next generation sequencing, we detected nucleic acid sequences from 2 novel viruses in the family Bunyaviridae and an emerging ...
Bouquet, Jerome +5 more
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Cost effective, experimentally robust differential-expression analysis for human/mammalian, pathogen and dual-species transcriptomics. [PDF]
, 2020 As sequencing read length has increased, researchers have quickly adopted longer reads for their experiments. Here, we examine 14 pathogen or host-pathogen differential gene expression data sets to assess whether using longer reads is warranted.
Bruno, Vincent M +9 more
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Geographical distribution and pathogenesis of ticks and tick-borne viral diseases
Frontiers in Microbiology, 2023 Ticks are obligatory hematophagous arthropods that harbor and transmit infectious pathogens to humans and animals. Tick species belonging to Amblyomma, Ixodes, Dermacentor, and Hyalomma genera may transmit certain viruses such as Bourbon virus (BRBV ...
Taif Shah +9 more
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