Heat shock proteins in health and disease: therapeutic targets or therapeutic agents? [PDF]
, 2001 For many years, heat shock or stress proteins have been regarded as intracellular molecules that have a range of housekeeping and cytoprotective functions, only being released into the extracellular environment in pathological situations such as necrotic
Pockley, A.G.
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Non-specific protein modifications by a phytochemical induce heat shock response for self-defense. [PDF]
PLoS ONE, 2013 Accumulated evidence shows that some phytochemicals provide beneficial effects for human health. Recently, a number of mechanistic studies have revealed that direct interactions between phytochemicals and functional proteins play significant roles in ...
Kohta Ohnishi +14 more
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Thermodynamics of Heat Shock Response [PDF]
, 1999 Production of heat shock proteins are induced when a living cell is exposed to a rise in temperature. The heat shock response of protein DnaK synthesis in E.coli for temperature shifts from temperature T to T plus 7 degrees, respectively to T minus 7 ...
A. Gragarov +19 more
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Small heat-shock proteins: important players in regulating cellular proteostasis [PDF]
, 2015 Small heat-shock proteins (sHsps) are a diverse family of intra-cellular molecular chaperone proteins that play a critical role in mitigating and preventing protein aggregation under stress conditions such as elevated temperature, oxidation and infection.
Carver, John A. +3 more
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Proteotoxic stress reprograms the chromatin landscape of SUMO modification [PDF]
, 2015 The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins.
Anne Seifert +4 more
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Heat Shock Proteins: Dynamic Biomolecules to Counter Plant Biotic and Abiotic Stresses
International Journal of Molecular Sciences, 2019 Due to the present scenario of climate change, plants have to evolve strategies to survive and perform under a plethora of biotic and abiotic stresses, which restrict plant productivity. Maintenance of plant protein functional conformation and preventing
Saeed ul Haq +7 more
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Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. [PDF]
, 2009 The aim of this study was to determine whether heat-shock pretreatment exerted a protective effect against sorbitol-induced apoptotic cell death in K562, U937 and HeLa cell lines and whether such protection was associated with a decreased cytochrome c
Aventaggiato, Michele +8 more
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Heat Shock Proteins in Lymphoma Immunotherapy
Frontiers in Immunology, 2021 Immunotherapy harnessing the host immune system for tumor destruction revolutionized oncology research and advanced treatment strategies for lymphoma patients.
Zarema Albakova +4 more
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Self-degradation of heat shock proteins [PDF]
, 1985 The 70-kDa heat shock protein of Drosophila decays in vivo at a much faster rate than other abundantly labeled proteins. Degradation also occurs in vitro, even during electrophoresis. It appears that this degradation is not mediated by a general protease
Buzin, Carolyn H. +2 more
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Analysis of Lupinus albus heat-shock granule proteins in response to high temperature stress
Biologia Plantarum, 2010 An important aspect of heat-shock response of lupin (Lupinus albus cv. Rio Maior) is the formation of cytoplasmic granular aggregates, called heat-shock granules (HSGs).
S. Cherian, R. B. Ferreira
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