Results 121 to 130 of about 568,583 (300)

A Randomized, Double-Blinded, Phase II Trial of Gemcitabine and Nab-Paclitaxel Plus Apatorsen or Placebo in Patients with Metastatic Pancreatic Cancer: The RAINIER Trial. [PDF]

, 2017
Lessons learnedThe addition of the heat shock protein 27 (Hsp27)-targeting antisense oligonucleotide, apatorsen, to a standard first-line chemotherapy regimen did not result in improved survival in unselected patients with metastatic pancreatic cancer ...
Al-Hazzouri, Ahmed, Bendell, Johanna C, DeBusk, Laura M, Earwood, Chris, Guo, Shuangli, Ko, Andrew H, Lane, Cassie M, Murphy, Patrick B, Peyton, James D, Rodriguez, Francisco A, Shipley, Dianna L, Tempero, Margaret A, Waterhouse, David M, Womack, Mark S, Xiong, Henry Q   +14 more
core   +1 more source

Polymorph‐Specific Electronic Transduction in WO3 during Molecular Sensing

Advanced Materials, EarlyView.
Metal‐oxide polymorphs with similar surface chemistry can nevertheless exhibit distinct sensing properties. In γ‐ and ε‐WO3, analyte adsorption appears comparable; yet, only ε‐WO3 induces a pronounced lattice electronic perturbation that accommodates charge in sub‐conduction band minimum states.
Matteo D'Andria, Meng Yin, Stefan Neuhauser, Vlasis G. Mavrantzas, Ying Chen, Ken Suzuki, Andreas T. Güntner   +6 more
wiley   +1 more source

Survival and Molting Incidence after Heat and Cold Shocks in Panstrongylus megistus Burmeister

Memorias do Instituto Oswaldo Cruz, 1999
Survival and molting incidence were studied after heat (40°C) and cold (0°C) shocks in specimens of Panstrongylus megistus with the aim of establishing its response to temperature stress under laboratory rearing conditions and to understand occasional ...
Simone L Garcia, Vera Lúcia CC Rodrigues, Nancy L Garcia, Antenor N Ferraz Filho, Maria Luiza S Mello   +4 more
doaj   +1 more source

Neuromorphic Electronics for Intelligence Everywhere: Emerging Devices, Flexible Platforms, and Scalable System Architectures

Advanced Materials, EarlyView.
The perspective presents an integrated view of neuromorphic technologies, from device physics to real‐time applicability, while highlighting the necessity of full‐stack co‐optimization. By outlining practical hardware‐level strategies to exploit device behavior and mitigate non‐idealities, it shows pathways for building efficient, scalable, and ...
Kapil Bhardwaj, Roshni Satheesh Babu, Yuxin Xia, Eva Bestelink, Radu Sporea, Nikos Hastas, Ioannis Zeimpekis, Dimitra G. Georgiadou, Sayani Majumdar   +8 more
wiley   +1 more source

Pulsed Laser‐Assisted Phase Engineering of Multimetallic Colloidal Nanocrystals With Complex Compositions

Advanced Materials, EarlyView.
The engineering of colloidal nanocrystals with complex compositions has emerged as a highly active area of research within nanomaterials science. This review covers key aspects of colloidal solid‐solution nanocrystal formation using pulsed laser irradiation.
Marina T. Candela, Sergio Triviño‐Sánchez, Andrés Guerrero‐Martínez, Luis M. Liz‐Marzán, Guillermo González‐Rubio   +4 more
wiley   +1 more source

Regulation of translation elongation and integrated stress response in heat-shocked neurons

Cell Reports
Summary: Neurons deviate from a canonical heat shock response (HSR). Here, we revealed that neuronal adaptation to heat shock accompanies a brake on mRNA translation, slowed elongating ribosomes, phosphorylation of eukaryotic elongation factor-2 (p-eEF2),
Caitlin M. Seluzicki, Milad Razavi-Mohseni, Fulya Türker, Priyal Patel, Boyang Hua, Michael A. Beer, Loyal Goff, Seth S. Margolis   +7 more
doaj   +1 more source

Global transcriptome analysis of the heat shock response of Bifidobacterium longum [PDF]

, 2017
Bifidobacteria are natural inhabitants of the human gastrointestinal tract and have been widely used as functional foods in different products. During industrial processing, bacterial cells undergo several stresses that can limit large-scale production ...
Arigoni, Fabrizio, Barretto, Caroline, Cuanoud, Gabriella, Delley, Michèle, Giliberti, Gabriele, Lariani, Sofiane, Pessi, Gabriella, Rezzonico, Enea   +7 more
core  

Surface Passivation of HgTe Nanocrystals Enabling EG/2 Open‐Circuit Voltage and Their Coupling to Dielectric Cavity for Narrow Detection

Advanced Materials, EarlyView.
This article explores how the integration of a thin shell, combined with optimized surface chemistry, enables the design of photodiodes based on short‐wave infrared HgTe nanocrystals. These photodiodes achieve an open‐circuit voltage greater than half the optical bandgap, which drastically reduces dark current. The article also explores the integration
Albin Colle, Clement Gureghian, Dario Mastrippolito, Mariarosa Cavallo, Jiho Roh, Marco Paye, Tommaso Gemo, Diogo Almeida, Adrien Khalili, Yoann Prado, Xavier Lafosse, Sandrine Ithurria, Mathieu G. Silly, Pavel Dudin, James K. Utterback, José Avila, Debora Pierucci, Emmanuel Lhuillier   +17 more
wiley   +1 more source

Fever, hyperthermia and the heat shock response

International Journal of Hyperthermia, 2013
The heat shock response is a highly conserved primitive response that is essential for survival against a wide range of stresses, including extremes of temperature. Fever is a more recently evolved response, during which organisms raise their core body temperature and temporarily subject themselves to thermal stress in the face of infections.
Ishwar S, Singh, Jeffrey D, Hasday
openaire   +2 more sources

Additive Manufacture of Diamond:Titanium Hybrid Quantum Sensors

Advanced Materials Interfaces, EarlyView.
ABSTRACT Additive manufacture represents one of the most advanced techniques for the creation of complex parts for applications as diverse as aerospace and implant surgery. However, a challenge with bespoke manufacture of metal parts is the incorporation of sensor elements in a fashion compatible with the 3D printing process.
Daniel Stavrevski, Marsilea A. Booth, David A. Broadway, Islay O. Robertson, Nour Mani, Joshua Zarins, Peter C. Sherrell, Amanda N. Abraham, Qiang Sun, Takeshi Ohshima, Brant C. Gibson, Kate Fox, Andrew D. Greentree   +12 more
wiley   +1 more source