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Translational regulation of the heat shock response
Molecular Biology Reports, 1994All organisms from bacteria to man respond to an exposure to higher than physiological temperatures by reprogramming their gene expression, leading to the increased synthesis of a unique set of proteins termed heat shock proteins (hsps). The hsps function as molecular chaperones in both normal and stressed cells.
J M, Sierra, J M, Zapata
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Developmental Regulation of the Heat-Shock Response
1989Cell differentiation in the development of multicellular organisms occurs as a consequence of the generation of chronologically and spatially distinct patterns of protein synthesis. These unique constellations of proteins confer on cells the functional and structural characteristics that enable them to perform their specialized roles in the organism ...
L W, Browder +4 more
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Regulation of Hsf1 and the Heat Shock Response
2020The heat shock response (HSR) is characterized by the induction of molecular chaperones following a sudden increase in temperature. In eukaryotes, the HSR comprises the set of genes controlled by the transcription factor Hsf1. The HSR is induced by defects in co-translational protein folding, ribosome biogenesis, organellar targeting of nascent ...
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Modulators of the eukaryotic heat shock response
Experimental Cell Research, 1986A wide variety of agents other than heat have been reported to induce or suppress heat shock protein (hsp) synthesis in eukaryotic cells. Such agents, termed 'modulators', include inhibitors of respiration, low molecular weight nutrients, oxygen, hormones, sulfhydryl reagents, ionophores and amino acid analogues.
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Heat shock proteins and the immune response
Immunology Today, 1990Heat shock proteins (HSPs) or stress proteins are produced by prokaryotic and eukaryotic cells in response to a variety of insults. After this original definition, it has become increasingly clear that HSPs can modify the function and destiny of other proteins and thus play an important role in numerous physiological processes.
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2014
Increased synthesis of heat shock proteins (hsps) was seen in response to physical and chemical stresses and during developmental transitions. Other stresses, particularly oxidative stress and osmotic stress, elicit characteristic changes in gene expression that overlap with one another and with heat stress.
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Increased synthesis of heat shock proteins (hsps) was seen in response to physical and chemical stresses and during developmental transitions. Other stresses, particularly oxidative stress and osmotic stress, elicit characteristic changes in gene expression that overlap with one another and with heat stress.
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Feedback Regulation of the Heat Shock Response
2005The heat shock response is triggered primarily by nonnative proteins accumulating in a stressed cell and results in increased expression of heat shock proteins (Hsps), i.e., of chaperones capable of participating in the refolding or elimination of nonnative proteins. Best known is the transcriptional part of this response that is mediated predominantly
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Pharmacological Modulation of the Heat Shock Response
2005Life presents a continuous series of stresses. Increasing the adaptation capacity of the organism is a long-term survival factor of various organisms and has become an attractive field of intensive therapeutic research. Induction of the heat shock response promotes survival after a wide variety of environmental stresses. Preclinical studies have proven
C, Soti, P, Csermely
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New horizons (Baltimore, Md.), 1995
Heat-shock proteins (HSPs) are a family of gene products that are expressed in response to stress in every living cell. This name was derived from early observations demonstrating their synthesis in fruit flies following elevations in temperature. More recently, a number of other environmental and pathological events have been observed to increase the ...
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Heat-shock proteins (HSPs) are a family of gene products that are expressed in response to stress in every living cell. This name was derived from early observations demonstrating their synthesis in fruit flies following elevations in temperature. More recently, a number of other environmental and pathological events have been observed to increase the ...
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Heat Shock Proteins and the Inflammatory Response
Annals of the New York Academy of Sciences, 1998ABSTRACT: The heat shock proteins (HSPs) are important in the cellular response to stress and in cellular homeostatic functions such as protein synthesis and protein transport across membranes. An emerging body of data supports a role for HSPs in the inflammatory response, suggesting that HSPs participate in cytokine signal transduction and in the ...
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