Results 71 to 80 of about 1,183,195 (322)

On space-time quasiconcave solutions of the heat equation

, 2019
In this paper we first obtain a constant rank theorem for the second fundamental form of the space-time level sets of a space-time quasiconcave solution of the heat equation.
Chen, Chuanqiang, Ma, Xinan, Salani, Paolo   +2 more
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Solution of the model problem of heat conduction with Bessel operator

Қарағанды университетінің хабаршысы. Математика сериясы
In this work, a model boundary value problem for a parabolic equation with a Bessel operator was investigated. The solution to the problem under consideration is sought as a sum of thermal potentials: the double-layer and volume potentials, which ...
N.K. Gulmanov, S.S. Kopbalina, A.O. Tanin   +2 more
doaj   +1 more source

A Novel Numerical Treatment to One Dimensional Heat and Wave Equations with Second Order Accuracy [PDF]

Computational Algorithms and Numerical Dimensions
Numerical solutions to partial differential equations (PDEs) play a vital role in modeling complex physical phenomena across scientific computing and engineering disciplines.
Muhammad Abid, Muhammad Shahid
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Crank-Nicolson method for solving uncertain heat equation. [PDF]

Soft comput, 2022
Liu J, Hao Y.
europepmc   +1 more source

Local times of anisotropic Gaussian random fields and stochastic heat equation [PDF]

, 2023
Davar Khoshnevisan, Cheuk Yin Lee
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Thermal Load and Heat Transfer in Dental Titanium Implants: An Ex Vivo-Based Exact Analytical/Numerical Solution to the 'Heat Equation'. [PDF]

Dent J (Basel), 2022
Panotopoulos GP, Panotopoulos GP, Haidar ZS.   +2 more
europepmc   +1 more source