Results 71 to 80 of about 1,170,486 (272)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

On space-time quasiconcave solutions of the heat equation

, 2019
In this paper we first obtain a constant rank theorem for the second fundamental form of the space-time level sets of a space-time quasiconcave solution of the heat equation.
Chen, Chuanqiang, Ma, Xinan, Salani, Paolo   +2 more
core  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Beyond the classical strong maximum principle: Sign-changing forcing term and flat solutions

Advances in Nonlinear Analysis
We show that the classical strong maximum principle, concerning positive supersolutions of linear elliptic equations vanishing on the boundary of the domain can be extended, under suitable conditions, to the case in which the forcing term is sign ...
Díaz Jesús Ildefonso, Hernández Jesús   +1 more
doaj   +1 more source

Crank-Nicolson method for solving uncertain heat equation. [PDF]

Soft comput, 2022
Liu J, Hao Y.
europepmc   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

A Novel Numerical Approach for Solving Initial Value Problems in Heat Equations Using Variational Regularization and Intelligent Particle Swarm Optimization

Proceedings of the International Conference on Applied Innovations in IT
In this article, we use the variational approach as a regularization tool to solve the initial value problem which appear in a heat partial differential equation.
H.K. Al-Mahdawi, Kilan M. Hussien, Ghassan K. Ali, Fadhil Kadhem Zaidan, Ali Subhi Alhumaima, Hussein Alkattan   +5 more
doaj   +1 more source

A Novel Numerical Treatment to One Dimensional Heat and Wave Equations with Second Order Accuracy [PDF]

Computational Algorithms and Numerical Dimensions
Numerical solutions to partial differential equations (PDEs) play a vital role in modeling complex physical phenomena across scientific computing and engineering disciplines.
Muhammad Abid, Muhammad Shahid
doaj   +1 more source

Thermal Load and Heat Transfer in Dental Titanium Implants: An Ex Vivo-Based Exact Analytical/Numerical Solution to the 'Heat Equation'. [PDF]

Dent J (Basel), 2022
Panotopoulos GP, Panotopoulos GP, Haidar ZS.   +2 more
europepmc   +1 more source