Results 71 to 80 of about 4,882,110 (280)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
A comparison with the three-zone model for flow boiling heat transfer in small diameter tubes [PDF]
, 2006 Flow boiling heat transfer experimental results, obtained in two stainless steel tubes of internal diameter 4.26 mm and 2.01 mm using R134a as the working fluid, indicate that the local heat transfer coefficient increases with heat flux and is ...
Karayiannis, TG +2 more
core +5 more sources
Terrestrial heat flow in Hungary [PDF]
Geofisica pura e applicata, 1956 The geothermal gradient in the Carpathian Basin lies between 40–70 C‡/km. According to careful measurements in shafts the value of terrestrial heat flow in the southern part of Hungary is (2.055–3.066)·10−6 cal/cm2 sec. These measurements are believed the first ever attempted in continental Europe. Systematic heat flow measurement are being extended to
openaire +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Research on Active Flow Control Method of NACA0012 Airfoil with Traveling Wave Structure [PDF]
Journal of Applied Fluid MechanicsTraveling wave is an innovative active flow control technique that can remarkably mitigate flow separation. This paper employs numerical simulation to examine how traveling wave structures affect the NACA0012 airfoil.
Q. Dai +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Floer Homology and the Heat Flow [PDF]
GAFA Geometric And Functional Analysis, 2006 ISSN:1420 ...
Salamon, Dietmar A., Weber, Joa
openaire +3 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Feature extraction via heat flow analogy
, 2009 Feature extraction is an important field of image processing and computer vision. Features can be classified as low-level and high-level. Low-level features do not give shape information of the objects, where the popular low-level feature ...
Direkoğlu, Cem
core +1 more source