Results 51 to 60 of about 1,077,007 (312)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Critical heat flux phenomena depending on pre-pressurization in transient heat input [PDF]

AIP Conference Proceedings, 2017
The critical heat flux (CHF) levels that occurred due to exponential heat inputs for varying periods to a 1.0-mm diameter horizontal cylinder immersed in various liquids were measured to develop an extended database on the effect of various pressures and subcoolings by photographic study. Two main mechanisms of CHF were found.
Jongdoc Park, Katsuya Fukuda, Qiusheng Liu   +2 more
openaire   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Modeling heat input when friction stir welding

IOP Conference Series: Materials Science and Engineering, 2019
Abstract An important element of friction stir welding technology is the determination of the temperature of the material in the mixing zone, which can be determined by calculating the amount of heat introduced into the welding zone. To determine this value, experimental studies were carried out on a stand in which the material to be ...
V Statsenko, A Sukhorada, V Lelyukhin
openaire   +1 more source

A Hot Channel

, 2007
This paper studies on-chip communication with non-ideal heat sinks. A channel model is proposed where the variance of the additive noise depends on the weighted sum of the past channel input powers.
Koch, Tobias, Lapidoth, Amos, Sotiriadis, Paul P.   +2 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A Multiple Response Prediction Model for Dissimilar AA-5083 and AA-6061 Friction Stir Welding Using a Combination of AMIS and Machine Learning

Computation, 2023
This study presents a methodology that combines artificial multiple intelligence systems (AMISs) and machine learning to forecast the ultimate tensile strength (UTS), maximum hardness (MH), and heat input (HI) of AA-5083 and AA-6061 friction stir welding.
Rungwasun Kraiklang, Chakat Chueadee, Ganokgarn Jirasirilerd, Worapot Sirirak, Sarayut Gonwirat   +4 more
doaj   +1 more source

High‐latitude Joule heating response to IMF inputs [PDF]

Journal of Geophysical Research: Space Physics, 2005
We evaluate the response of the high‐latitude Joule heating to orientation and magnitude of the interplanetary magnetic field (IMF). Approximately 9000 individual Joule heating patterns derived from data assimilation for the northern hemisphere were used to develop averaged and hemispherically integrated Joule power maps for the northern hemisphere ...
McHarg, M., Chun, F., Knipp, D., Lu, G., Emery, B., Ridley, A.   +5 more
openaire   +2 more sources

Effects of heat input rates on T-1 and T-1A steel welds [PDF]

, 1967
Technology of T-1 and T-1A steels is emphasized in investigation of their weld-fabrication.
Davis, R. A., Olsen, M. G., Worden, S. W.   +2 more
core   +1 more source