Results 51 to 60 of about 176,436 (256)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Heat load patterns in district heating substations
Applied Energy, 2013 AbstractFuture smart energy grids will require more information exchange between interfaces in the energy system. One interface where dearth of information exists is in district heating substations, being the interfaces between the distribution network and the customer building heating systems. Previously, manual meter readings were collected once or a
Gadd, Henrik, Werner, Sven
openaire +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Nuclear FusionA model for the plasma evolution during the current quench is presented in this paper: it allows to simulate the evolution of the phenomenon, carry on parametric studies and calculate the heat loads on the tokamak first wall.
G. Pautasso +4 more
doaj +1 more source
发电技术By analyzing the change laws of flue gas temperature, steam temperature and working fluid mass flow during a power failure accident in a 660 MW power plant, the change laws of heat load in dense phase zone, transition zone and dilute phase zone over time
DENG Qigang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Design and Analysis of CO2 Refrigeration System for Indoor Ice Rink with Heat Recovery
Zhileng xuebao, 2022 The main energy requirements of indoor ice rinks are refrigeration and heat. If the refrigeration system can simultaneously meet the refrigeration and heating loads, the system efficiency can be significantly improved.
Yao Yao +6 more
doaj
XM_HeatForecast: Heating Load Forecasting in Smart District Heating Networks
, 2020 Forecasting is an important task for intelligent agents involved in dynamical processes. A specific application domain concerns district heating networks, in which the future heating load generated by centralized power plants and distributed to buildings must be optimized for better plant maintenance, energy consumption and environmental impact.
Federico Bianchi +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source