Results 61 to 70 of about 2,796,382 (285)
Journal of Applied Animal Research, 2019 Forty-six Dorper, 46 Katahdin, and 43 St. Croix female sheep from four regions of the USA were used to evaluate responses to high heat load index (HLI) conditions.
Dereje Tadesse +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Heat load patterns in district heating substations
Applied Energy, 2013 AbstractFuture smart energy grids will require more information exchange between interfaces in the energy system. One interface where dearth of information exists is in district heating substations, being the interfaces between the distribution network and the customer building heating systems. Previously, manual meter readings were collected once or a
Gadd, Henrik, Werner, Sven
openaire +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Nuclear FusionA model for the plasma evolution during the current quench is presented in this paper: it allows to simulate the evolution of the phenomenon, carry on parametric studies and calculate the heat loads on the tokamak first wall.
G. Pautasso +4 more
doaj +1 more source
发电技术By analyzing the change laws of flue gas temperature, steam temperature and working fluid mass flow during a power failure accident in a 660 MW power plant, the change laws of heat load in dense phase zone, transition zone and dilute phase zone over time
DENG Qigang +6 more
doaj +1 more source
XM_HeatForecast: Heating Load Forecasting in Smart District Heating Networks
, 2020 Forecasting is an important task for intelligent agents involved in dynamical processes. A specific application domain concerns district heating networks, in which the future heating load generated by centralized power plants and distributed to buildings must be optimized for better plant maintenance, energy consumption and environmental impact.
Federico Bianchi +3 more
openaire +3 more sources